Complete NR565 Final Exam Study Guide
• Thyroid o Thyrotropin-releasing hormone (TRH) from the hypothalamus stimulates o release of thyroid-stimulating hormone (TSH) from the pituitary. o TSH stimulates all aspects of thyroid function, ▪ including the release of triiodothyronine (T3) and thyroxine (T4). ▪ T3 and T4 act on the pituitary to suppress further TSH release. o Diagnosis & Evaluation ▪ What labs are used to diagnose? ▪ Serum TSH determinations are used primarily for screening and diagnosis of hypothyroidism and for monitoring replacement therapy in hypothyroid patients. ▪ Serum TSH determinations can also distinguish primary hypothyroidism from secondary hypothyroidism. In primary (thyroidal) hypothyroidism, TSH levels are high. However, in secondary hypothyroidism (hypothyroidism resulting from anterior pituitary dysfunction), TSH levels are low, normal, or even slightly elevated—despite low T3 and T4. ▪ Serum Thyroxine Test
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