NURS 660 SUM 2023/24 Exam 1 dopamine, serotonin, abnl movements, (Already Passed!)

dopamine hypothesis correct answers the theory that schizophrenia results from excessive activity of the neurotransmitter dopamine What is the path of dopamine suppression by 5-HT? correct answers 5-HT2A antagonism by atypical antipsychotics decrease serotonin release, thereby stimulating downstream dopamine. Increased dopamine reduces glutamate which inhibits release of inhibitory GABA (inhibits dopamine) Mesolimbic dopamine hypothesis: Hyperactivity of dopamine neurons in the mesolimbic dopamine pathway cause what symptoms of schizophrenia correct answers symptoms of psychosis such as delusions and hallucinations. This pathway is also involved in pleasure, reward, and reinforcing behavior, and many drugs of abuse interact here. What conditions other than schizophrenia may cause positive symptoms? correct answers Depression, mania, dementia, drug-induced psychosis Hyperactivity of the _______________________________ pathway may also play a role in the hostility and aggression found with schizophrenia. correct answers mesolimbic dopamine pathway If there is too much dopamine in the basal ganglia causes what type of movements? correct answers chorea, dyskinesia and tics-- imvoluntary hyperactivity of muscle movements Deficiency of dopamine in the basal ganglia can also causes what types of movement? correct answers akathesia and dystonia -- decreased voluntary muscular control or movement. What is chorea? correct answers Involuntary, rapid, irregular and jerky movements especially of hips, shoulders and face what is akathesia correct answers Difficulty staying still, motor restlessness what is dystonia correct answers Involuntary sustained muscle contractions, producing twisting or squeezing movement and abnormal postures mesolimbic- hostility, aggression correct answers ham-l--abnormal pathway/symptom what is an example of a 5-HT1a agonist? correct answers buspar what is tardive dyskinesia? correct answers repetitive, jerking movements that occur in the face. neck and tongue