UNE CHEM 1005: MEDICAL BIOCHEMISTRY FINAL EXAM

UNE CHEM 1005: MEDICAL BIOCHEMISTRY FINAL EXAM Carnitine palmitoyl transferase - transfers acyl groups from CoA to carnitine & vice versa - inhibited by malonyl-CoA ketone bodies - acetoacetate, β-hydroxybutyrate, acetone - oxidized as fuel source in extreme fasting d-3-hydroxybutyrate dehydrogenase interconversion of acetoacetate and 3-hydroxybutyrate acetone yielded by spontaneous decarboxylation of acetoacetate; waste product acetoacetate and 3-hydroxybutyrate - ketone bodies produced during fasting - used for energy in various tissues hyperglycemia and ketogenesis - occurs in fasted state - loss of insulin (type 1 diabetes) Ketogenesis the process by which excess acteyl-CoA is converted into ketone bodies products of B-oxidation of fatty acids - NADH - FADH2 - acteyl-CoA regulatory step in fatty acid synthesis production of malonyl-CoA by acetyl-CoA carboxylase acetyl-CoA carboxylase is inhibited by - Palmitoyl-CoA