ONS/ONCC CHEMOTHERAPY BIOTHERAPY CERTIFICATION LATEST (2 DIFFERENT VERSIONS ) 150 REAL EXAM QUESTIONS AND ANSWERS| NEW UPDATE

ONS/ONCC CHEMOTHERAPY BIOTHERAPY CERTIFICATION LATEST (2 DIFFERENT VERSIONS ) 150 REAL EXAM QUESTIONS AND ANSWERS| NEW UPDATE VERSION 1 Lesson 1: Foundations to Set the Stage Focusing on Cellular Structure and Function The Normal Cell Cycle - ANSWER- -The cell cycle refers to the ordered seres of processes of DNA replication and mitosis, or cell division -Cell nucleus regulates these processes by gathering and processing complexes molecular information Interphase and Mitotic Phase - ANSWER- Cell division produces two identical cells through these two major phases During interphase: - ANSWER- Cell grows and DNA is replicated through the following three steps: 1: First growth phase (G1 or first gap) 2: Synthesis phase (S phase) 3:Mitotic Phse (M phase) First Growth Phase (G1 or first gap) - ANSWER- -cells increase in size -reproduce RNA -"quality assurance" test that the cell will be ready to synthesis DNA -Length of time is variable, can be from hours to days Synthesis Phase (S phase) - ANSWER- -DNA replicates -Results in the formation of identical pairs of DNA (chromatids) -which are attached a t the centromere -lasts 2-10 hours Mitotic Phase (M phase) - ANSWER- -Replicated chromosomes are aligned, separated, and move into 2 new, identical daughter cells -takes about 30-60 minutes Major points of cell regulation are entry and exit from - ANSWER- -G1 checkpoint -S Phase -G2 checkpoint -M phase Restriction Point - ANSWER- -The transition from the resting phase into an actively dividing phase (G0-G1) is a point where cellular transformation can occur -During this time, cells pass through a transition phase known as a restriction point -Extracellular growth factors trigger reentry into G1, and GF are required to send the cells past the restriction point, or the point of no return G0 Phase (resting phase) - ANSWER- -After mitosis, cells may enter back into the G1 phase or go into a resting phase, known as G0 -Most cells in the human body reside in G0 -Exceptions to this are those that are (Resting in G0 phase) - ANSWER- - Exceptions to this are those that are metabollically active, such as -granulocytes -and the epithelium of the GI tract Cell Cycling Time - ANSWER- Amount of time from mitosis to mitosis Cell cycle video and image - ANSWER tion__how_the_cell_cycle_ Check points in the Cell Cycle: Keeping it All Under Control - ANSWER- -The cell cycle is carefully controlled through a series of checkpoints -Variation in duplication or distribution of chromosomes during cell division can alter the genetic information passed on to daughter cells, leading to cellular dysfunction and disease, such as cancer -These checkpoints monitor for DNA integrity and control progression through mitosis Progression through the cell cycle is controlled through two proteins: - ANSWER1. cyclines (D, E, A, B) 2. Cyclin-dependent kinases (CDKs) -Cyclin-CDK complex allows the cell to progress through each phase of the cell cycle Locations of proteins Cyclins (D, E, A, B) and CDKs - ANSWER- -(G0-G1) : Cyclin D and CDK 4/6 -Early S: Cyclin E and CDK 1/2 -Late S: Cyclin A and CDK 1/2 -G2: CDK 1/2 and cyclin A -Before M: CDK 1 and Cyclin B Inhibitory proteins - ANSWER- -prevent progression of the cycle when DNA damage is detected -An example of an inhibitory protein is p53 (AKA TP53) DNA Damage Checkpoints - ANSWER- -If DNA damage is present, cells are programmed to stop dividing or undergo apoptosis (programmed cell death) -The retinoblastoma protein (Rb), p53, and p21 are some of the most wellunderstood inhibitory proteins (IP)