ISBB questions and answers graded A+ 2023 passed

ISBB questions.Upon adding the indicator system in a T. pallidum complement fixation test, hemolysis was observed. This indicates Negative reaction, T. pallidum antibody absent A patient being positive for the Vi antigen in Widal test means: 1. Patient is also positive for envelope antigen 2. Patient is carrier of S. typhi 3. Patient is positive for the somatic antigen 4. Patient has an active typhoid fever Patient is also positive for envelope antigen and a carrier of The following statements about Ficoll-Hypaque are TRUE, EXCEPT: A. Ficoll-Hypaque solution has a specific gravity of 1.077-1.114 B. It is used to separate peripheral blood mononuclear cells (PBMC) from granulocytes C. Upon centrifugation, 3 layers are formed including the Ficoll-Hypaque medium upon centrifugation, 3 layers are formed including the Ficoll-Hypaque DOT and IATA 2007 "clinical specimen/diagnostic specimen" should be changed to Biological substance category B Genotype R2 r would give what reactions? Anti-D anti-C anti-E anti-c anti-e + / - / + + + If two Rh-positive parents are heterozygotes, what are the possibilities for the Rh typing of their children? 75% Rh(+) kids 25% Rh (-) kids All of the following statements are true regarding the A2 blood group, EXCEPT: * A. Dolichos biflorus lectin generally does not agglutinate A2 RBCs B. A2 RBCs have more A antigen than A1 RBCs C. A2 RBCs are agglutinated with anti-A antisera D. Most A2 individuals have the same form of anti-B as A1 individuals A2 RBCs have more A antigen than A1 RBCs One of the main physiologic functions of this interleukin is to promote the growth and differentiation of eosinophils and to activate eosinophils to kill parasites more effectively: IL-4 OX-K antigen is derived from ____; while OX-2 and OX-19 antigens are derived from ____. These antigens are used for the _____ agglutination test OX-K antigen: P. mirabilis OX-2 & OX-19: P. vulgaris Weil Felix Which unit should be selected for exchange transfusion if the newborn is group A Rh+ and the mother is group A Rh+ with anti-c antibodies? type A, R1R1 A 40-year old secretary reported that she had sort of brain covering graft from a cadaver during surgery from her car accident five years ago. She has never donated blood since that accident. The donor is eligible to donate blood never A 14-year old boy needs a red cell transfusion. He has a documented history of IgA deficiency with a vague history of a serious reaction to a previous transfusion. Assuming that you have all of the following readily available in your Blood Bank, which is the best choice? deglycerolyzed RBCs The A gene is responsible for coding a-3-N-acetylgalactosaminyltransferase Enzo donated his right kidney to his twin brother Lucas, who was suffering from CHF. Which of the following types of tissue transplant was exemplified by the given situation? syngraft CMV (cytomegalovirus) infection in newborn transfusion can be prevented by removing which of these components in donor blood? leukocytes State during which a cell cannot become activated by exposure to its antigen anergy A person with BO, HH, se, Le genes will have which of the following combination of substances on their red cells? B, H, Lea A friend of yours is concerned about the fidelity of his wife. He tells that he is blood type A and his wife is blood type B. Their newborn child is type O. if all the blood types are correct, how is this possible? both parents are heterozygous for their ABO genes Calculate the number of units to crossmatch if a patient needs 3 units and has antibodies to 2 antigens with 53% and 78% frequency 29 units The following are characteristics of Type IV hypersensitivity reaction, EXCEPT: 1. There is subsequent production of cytokines 2. Proliferation of additional lymphocytes and macrophages 3. It occurs through memory T-cell meditated process 4. It arises due to systemic or local deposition of antigen-antibody complexes arises due to systemic or local deposition of antigen-antibody complexes What has happened in a titer, if tubes Nos. 5-7 show a stronger reaction than tube Nos.1-4? prozone reaction Which cluster of differentiation (CD) marker appears during the first stage of T-cell development and remains present as an identifying marker for T cells? CD2 Stage of B cell development where the synthesis of heavy chains belonging to belonging to IgM immunoglobulins can be observed pre-B cells Monoclonal antibody used as a therapeutic agent for colorectal cancer cetuximab In gel technology, agglutination was observed and was described as "majority of agglutinates are at the upper half of the column." How would you rate the reaction? 3+ Jane plans to donate blood, but she has taken Soriatane for her psoriasis. What should you do? 3 years The following are the mechanisms involved in the development of DIHA and the drug most commonly involved. Which is improperly matched? A. Drug adsorption - Penicillin B. Immune complex deposition - Rifampin C. Autoantibody formation - Methyldopa D. Membrane modification - Phenacetin Membrane modification - Phenacetin What determines the isotype of an immunoglobulin antibody? Defined by the C-terminal of the heavy chain Function of suppressor T cells Suppress function of cytotoxic and helper tcell Also known as regualtory T cell Prevents cytotoxic cells from causing excessive immune reactions Why are calcium ions necessary in the activation of complement activity? They stabilize the c1q, c1r, and c1s unit