NURS 5315 Disorders of the Immune System

Disorders of the Immune System 2. Differentiate between the etiology, clinical manifestations and pathophysiology of select disorders of the immune system. Hypersensitivity: an altered immunologic response to an antigen that results in disease or damage to the host. Hypersensitivity reaction: can be classified in 2 ways - by the source of the antigen that the immune system is attacking (allergy, autoimmunity, alloimmunity) - by the mechanism that causes the disease (types I, II, III, IV) a. Evaluate the etiology, clinical manifestations and pathophysiology of Type I, Type II, Type III, and Type IV hypersensitivities and describe the implications clinical practice. -the four mechanisms are interrelated, and in most hypersensitivity reactions, several mechanism can be at work simultaneously or sequentially Hypersensitivity Etiology Clinical Manifestations Pathophysiology Type I (IgE-Mediated Hypersensitivity Reactions) Mediated by antigenspecific IgE and the products of tissue mast cells. Most type I reactions occur against environmental