580 EXAM 2QUESTIONS WITH CORRECT ANSWERS {VERIFIED}

T/F: self suffciency in growth signals is a hallmark of cancer - True T/F: enhanced sensitivity to anti-growth signals is a hallmark of cancer - False T/F: tumor promoting inflammation is a hallmark of cancer - True T/F: limited replicative potential is a hallmark of cancer - False Genomic instability and mutation - PARP inhibitors Enabling replicative immortality - telomerase inhibitors Avoiding immune detection - immune activating anti-CTLA4 mAb Sustaining proliferative signaling - EGFR inhibitors evading growth suppression - cyclin dependent kinase (CDK) inhibitors receptor tyrosine kinases - EGFR apoptosis inhibition - p13K/Akt/mTOR cell proliferation - ras/mek/mapk select all possible mechanisms that may contribute to the development of resistance to EGFR inhibition a) activation of complementary signaling pathway b)activating EGFR downstream targets C) secondary mutations D) inhibition of gene expression - Resistance to EGFR inhibition: A: activation of complementary signaling pathway, B: activating EGFR downstream targets, C: secondary mutations