NSG 6005 Week 2 Pharmacology Quiz, NSG 6005 Week 1 Pharmacology Quiz, NSG6005 week 3 quiz, Week 5 Final EXAM QUESTIONS With ANSWERS LATEST

NSG 6005 Week 2 Pharmacology Quiz, NSG 6005 Week 1 Pharmacology Quiz, NSG6005 week 3 quiz, Week 5 Final EXAM QUESTIONS With ANSWERS LATEST UPDATE 2023/2024 GRADED A+ The major reason for not crushing a sustained release capsule is that, if crushed, the coated beads of the drugs could possibly result in: o Disintegration o Toxicity o Malabsorption o Deterioration - ANSWER o Toxicity Drugs that have a significant first pass effect: o Must be given by enteral (oral) route only o Bypass the hepatic circulation o Are rapidly metabolized by the liver and may have little if any desired action o Are converted by the liver to more active in fat-soluble forms - ANSWER o Are rapidly metabolized by the liver and may have little if any desired action When obtaining a drug history from Harold, he gives you a complete list of his prescription medications. He denies taking any other drugs, but you find that he occasionally takes aspirin for his arthritis flare-ups. This is an example of: o His appropriately only telling you about his regularly prescribed medications o His hiding information regarding his inappropriate use of aspirin from you o His common misconception that intermittently taking OTC medications are not an important part of his drug history o A common misuse of OTC aspirin - ANSWER o His common misconception that intermittently taking OTC medications are not an important part of his drug history Drugs that use CYP3A4 isoenzymes for metabolism may: o Induce the metabolism of another drug o Inhibit the metabolism of another drug o Both A and B o Neither A nor B - ANSWER o Both A and B A twenty four year old male received multiple fractures in a motor vehicle accident that required significant amounts of opioid medication to treat his pain. He is at risk for Type ____ ADR when he no longer requires the opioids. o A o C o E o G - ANSWER o E Infants and young children are at higher risk of ADRs due to: o Immature renal function in schoolage children o Lack of safety and efficacy studies in the pediatric population o Children's skin being thicker than adults, requiring higher dosages of topical medication o Infant boys having a higher proportion of muscle mass, leading to a higher volume of distribution - ANSWER o Lack of safety and efficacy studies in the pediatric population The type of ADR that is the result of an unwanted but otherwise normal pharmacological action of a drug given in the usual therapeutic dose is: o Type A o Type B o Type C o Type D - ANSWER o Type A A nurse practitioner would prescribe the liquid form of ibuprofen for a six-year-old because: o Drugs given in liquid form are less irritating to the stomach. o A six-year-old may have problems swallowing a pill. o Liquid forms of medication eliminate the concern for first-pass effect. o Liquid ibuprofen does not have to be dosed as often as tablet form. - ANSWER o A six-year-old may have problems swallowing a pill. The role of the nurse practitioner in the use of herbal medication is to: o Maintain competence in the prescribing of common herbal remedies. o Recommend common OTC herbs to patients. o Educate patients and guide them to appropriate sources of care. o Encourage patients to not use herbal therapy due to the documented dangers. - ANSWER o Educate patients and guide them to appropriate sources of care. Genetic polymorphisms account for differences in metabolism, including: o Poor metabolizers (PMs) that lack a working enzyme o Intermediate metabolizers (IMs) that have one working, wild-type allele and one mutant allele o Extensive metabolizers (EMs), with two normally functioning alleles o All of the above - ANSWER o All of the above The elderly are at high risk of ADRs due to: o Having greater muscle mass than younger adults, leading to higher volume of distribution o The extensive studies that have been conducted on drug safety in this age group o The blood-brain barrier being less permeable, requiring higher doses to achieve therapeutic effect o Age-related decrease in renal function - ANSWER o Age-related decrease in renal function Which of the following factors may adversely affect a patient's adherence to a therapeutic drug regimen? o Complexity of the drug regimen o Patient's perception of the potential adverse effects of the drugs o Both A and B o Neither A nor B - ANSWER o Both A and B The first step in the prescribing process according to the World Health Organization is: o Choosing the treatment o Educating the patient about the medication o Diagnosing the patient's problem o Starting the treatment - ANSWER o Diagnosing the patient's problem Patients with psychiatric illnesses have adherence rates to their drug regimen between 35% and 60%. To improve adherence in this population, prescribe drugs: o With a longer half-life so that missed doses produce a longer taper on the drug curve o In oral formulations that are more easily taken o That do not require frequent monitoring o Combined with patient education about the need to adhere even when symptoms are absent - ANSWER o With a longer half-life so that missed doses produce a longer taper on the drug curve An advantage of prescribing a sublingual medication is that the medication is: o Absorbed rapidly o Excreted rapidly o Metabolized minimally o Distributed equally - ANSWER o Absorbed rapidly The time required for the amount of drug in the body to decrease by 50% is called: o Steady state o Half-life o Phase II metabolism o Reduced bioavailability time - ANSWER o Half-life A patient may develop neutropenia from using topical Silvadene for burns. Neutropenia is: o A cytotoxic hypersensitivity reaction o An immune complex hypersensitivity o An immediate hypersensitivity reaction o A delayed hypersensitivity reaction - ANSWER o A cytotoxic hypersensitivity reaction Steady state is: o The point on the drug concentration curve when absorption exceeds excretion o When the amount of drug in the body remains constant o When the amount of drug in the body stays below the minimum toxic concentration (MTC) o All of the above - ANSWER o When the amount of drug in the body remains constant What impact does developmental variation in renal function has on prescribing for infants and children? a. Lower doses of renal he excreted drugs may be prescribed to infants younger than six months b. Higher doses of water-soluble drugs may need to be prescribed due to increased renal excretion c. Renal excretion rates have no impact on prescribing d. Parents need to be instructed on whether drugs are renal he excreted or not - ANSWER a. Lower doses of renal he excreted drugs may be prescribed to infants younger than six months What impact does the developmental variation in phase I enzymes has on pediatric prescribing? a. None; phase I enzymes are stable throughout childhood b. Children should always be prescribed lower than adult doses per weight due to low enzyme activity until puberty c. Children should always be prescribed higher than adult doses per weight due to high