AUA MED 1 – GI Questions With Complete Solutions

What is the rate limiting enzyme of glycolysis? correct answer: phosphofructokinase-1 (PFK-1) What activates phosphofructokinase-1? correct answer: AMP + fructose 2,6-bisphosphate What inhibits phosphofructokinase-1? correct answer: ATP + citrate What is the rate limiting enzyme of gluconeogenesis? correct answer: fructose-1,6-bisphosphatase 1 What inhibits fructose-1,6-bisphosphatase 1? correct answer: AMP + fructose-2,6-bisphosphate What is the rate limiting enzyme of the TCA cycle? correct answer: isocitrate dehydrogenase What inhibits isocitrate dehydrogenase? correct answer: ATP + NADH What activates isocitrate dehydrogenase? correct answer: ADP and NAD+ What is the rate limiting enzyme of glycogenesis? correct answer: glycogen synthase What activates glycogen synthase? correct answer: glucose-6-phosphate, insulin, + cortisol What inhibits glycogen synthase? correct answer: epinephrine + glucagon What is the rate limiting enzyme of glycogenolysis? correct answer: glycogen phosphorylase What activates glycogen phosphorylase? correct answer: AMP, epinephrine, + glucagon Whaat inhibits glycogen phosphorylase? correct answer: glucose-6-phosphate, insulin, + ATP What is the rate limiting enzyme of the HMP shunt? correct answer: Glucose-6-phosphate dehydrogenase (G6PD) What activates glucose-6-phosphate dehydrogenase (G6PD) ? correct answer: NADP+