Chemotherapy Biotherapy Certification

Chemotherapy Biotherapy Certification Resources - ANSWER LESSON 1: Cell cycle - ANSWER g1- increase in size s- dna replicated g2- cell enlarge and ready to divide m phase- 2 hours mitosis - ANSWER 4 stages, prophase, metaphase, anaphase, telophase -chemo targets certain points in the process apoptosis - ANSWER programmed cell death hematopoiesis - ANSWER formation of blood cells & how cells differentiate -myeloid: pre cells mature into RBCs, platelets and WBCs -lymphoid: pre cells- mature into WBCS Principles of Biotherapy: p51-95 immunology - ANSWER -defense against foreign organisms, homeostasis (destroy aged cells), surveillance immune responses - ANSWER innate: primary line of defense, non specific, no memory adaptive: secondary line of defence with specific memry cytokines - ANSWER -effect growth and differentiation of WBC -interferons, tumor necrosis factors, growth factos and interleukins -small protein molecules released by cells throughout body providing comunication between cells of the immune system -regular antiboddy production and function of b cells vaccines for cancer prevention - ANSWER -hep B prevents hepatitis and hepatocellular carcinoma -hpv vaccine filgrastim aka neupogen - ANSWER SC or IV to derease infection in patients with neutropenic fever associated with myelosuppressive anticancer treatments for nonmyeloid malignancies tbo-filgramstim/ pegfilgrastim - ANSWER reduce duration of neutroenia in patients with non myeloid malignancies palifermin - ANSWER IV to dec incidence of oral mucositis in patients with hem malignanies before BMT sargramostim - ANSWER aka leukine - patients with AML following chemo to shorten neutrophil recovery and reduce incidence of infection IFN gamma - ANSWER reduce frequency and severity o infections related to granulomatous disease aldeleukin - ANSWER treat renal cell carcinoma and metastatic melanoma oprevelkin - ANSWER prevent severe thrombocytopenia and refuce need for platelet transfusions in patients with nonmyeloid malig plerixafor - ANSWER with filgrastim to mobilize hematopoeitc stem cells for collection from peripheral blood of patients sipuleucel - ANSWER castrate resistant prostate cancer rituximab - ANSWER rituxan- treatment of relapsed or refractory low grade follicular b cell NHL_ first line traetment in combo with chemo in patients with response -can treat severe rheumatoid arthritis -can have severe reactions (hypotension, urticaria, angiodema, hypoxia, rigors, dyspnea, chills, fever, nausea, rash, renal tox) -premed with tylenol and benadryl -slow infusion to resolve some side effects, side effects reduce with each infusion immune system - ANSWER 1st line: skin , ucous membrane, gut flora second line: phagocytes: 3rd line antibodies, t and b cells