MN 553 (Advanced Pharmacology) Questions with Answers Graded A+

Rifampin is a nonspecific CYP450 inducer that may: Question options: Lead to toxic levels of rifampin and must be monitored closely Cause toxic levels of drugs, such as oral contraceptives, when coadministered Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure Cause nonspecific changes in drug metabolism Question 3 1 / 1 point Inhibition of P-glycoprotein by a drug such as quinidine may lead to: Question options: Decreased therapeutic levels of quinidine Increased therapeutic levels of quinidine Decreased levels of a coadministered drug, such as digoxin, that requires Pglycoprotein for absorption and elimination Increased levels of a coadministered drug, such as digoxin, that requires Pglycoprotein for absorption and elimination Question 4 1 / 1 point Warfarin resistance may be seen in patients with VCORC1 mutation, leading to: Question options: Toxic levels of warfarin building up Decreased response to warfarin Increased risk for significant drug interactions with warfarin Less risk of drug interactions with warfarin Question 5 1 / 1 point Pharmacogenetic testing is required by the U.S. Food and Drug Administration prior to prescribing: Question options: Erythromycin Digoxin Cetuximab Rifampin Question 6 1 / 1 point Carbamazepine has a Black Box Warning recommending testing for the HLA-B*1502 allele in patients with Asian ancestry prior to starting therapy due to: Question options: Decreased effectiveness of carbamazepine in treating seizures in Asian patients with the HLA-B*1502 allele Increased risk for drug interactions in Asian patients with the HLA-B*1502 allele Increased risk for Stevens-Johnson syndrome in Asian patients with HLA-B*1502 Allele Patients who have the HLA-B*1502 allele being more likely to have a resistance to carbamazepine Question 7 1 / 1 point A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is inactivated by the body may lead to: Question options: Decreased effectiveness of irinotecan in the treatment of cancer Increased adverse drug reactions, such as neutropenia Delayed metabolism of the prodrug irinotecan into the active metabolite SN-38 Increased concerns for irinotecan being carcinogenic Question 8 1 / 1 point A good history of herb and supplement use is critical before prescribing because approximately ____ % of patients in the United States are using herbal products. Question options: 10 5 38 70 Question 9 1 / 1 point A potential harmful effect on patients who take some herbal medication is: Question options: Constipation Lead poisoning Diarrhea Life-threatening rash Question 10 1 / 1 point A thorough understanding of herbs is critical to patient safety. An example is the use of cinnamon to treat type II diabetes. It is important the patient uses Ceylon cinnamon, as the commercially available cassia cinnamon contains: Question options: Coumadin, which may lead to bleeding problems Coumarin, which can cause liver and kidney damage Cinnamic aldehyde, which is toxic to the kidney Cinnamate eugenol, which is toxic to the liver