AAMC PRACTICE EXAM #5 C/P

Compound 1 is used to treat HIV infection based on its ability to act as: - Answer- B. an antagonist - P2 states that Compound 1 is a potent HIV protease inhibitor - HIV protease is an enzyme that is targeted to treat HIV infection - an antagonist impedes on the normal function of a system CORRECT How many stereoisomers of Compound 1 exist? - Answer- C. 32 There are 5 chiral carbons indicated in the figure 2^n rule n= # chiral carbons CORRECT Why do kidney stones form in some individuals treated with Compound 1? - Answer- B. [Ca2+][C2O42-] Ksp Ksp is the solubility product constant - the formation of kidney stones are composed of calcium oxalate CaC2O4 CORRECT The peptide bond between which two amino acid residues is cleaved by HIV protease? - Answer- D. Phe and Proline Phenylalanine Proline Proline has N ring Ph - Phenyl group CORRECT Which image best illustrates the electric field lines between the inside of an axon and the surrounding extracellular solution? - Answer- B. Electric field pointing from extracellular fluid to axon interior - An axon is negatively charged because there the concentration of Na+ is higher outside of the cell