NBME Pathology verified 100% full solution
NBME Pathology verified 100% full solution Apoptosis: - ANSWER-Programmed cell death. REQUIRES ATP. Can occur via the intrinsic or extrinsic pathways, both of which involve activation of cytosolic caspases which mediate cellular breakdown. ***Unlike necrosis, apoptosis does not involve significant inflammation. Involves eosinophilic cytoplasm, cell shrinkage, pyknosis and basophilia, membrane blebbing and karyorrhexis, and formation of apoptotic bodies which are phagocytosed. **DNA laddering is a sensitive indicator of apoptosis** Occurs because during karyorrhexis endonucleases yield 180bp fragments.
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nbme pathology verified 100 full solution
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