PCOA exam with complete solutions - Pharmaceutical Sciences
What effects does change in structure and as a result biodistribution have on a drug? (Physico-Chemical Properties of Drugs) Changes the solubility, metabolism, and excretion properties of the drug within the limits of the biological target. Electrolytes Ionic/ weak acid or base Hydrogen Bonds Hydrogen bonds form between polar groups Interaction between an electronegative atom (O, N, S) and a polarized hydrogen. Polarized H is one that is bound to an electronegative atom. Water can accept and donate H-bonds. Competition between H-bonding between water molecules v. H-bonding between drug and water molecules Halogenated hydrocarbon contain C, H, and halides (CL, F, I) Alcohols Contain a hydrogen bond donor and acceptor R-OH aldehyde O=C-H pKa value Definition: a measure of the tendency to give up a proton indicates the acid or base properties of a particular functional group As pKa decreases, the better the acid, the easier it is to give up a proton. pKa of Carboxylic Acids pKa = 3-5 pKa of beta-Dicarbonyl compounds pKa = 3-5 Imide pKa = 4-5 N-arylsulfonimide pKa = 5-6
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