CPPS 325 Pre-Midterm 1 questions with correct answers
Charles-Edouard Brown-Sequard - Answer Injected himself with ground-up animal testicles led to development of modern hormone therapy. Largely placebo Basic Principle of a Cell Signalling Pathway - Answer Stimuli - Receptors - Transducers - Amplifiers - Messengers - Sensors and Effectors - Cellular Responses (Fertilization, Proliferation, Differentiation, Secretion, Contraction, Metabolism, Membrane Excitability, Learning and Memory). Ligand Receptor Interaction - Answer A single ligand will bind to receptor and, until it detaches from receptor will keep the signal going to induce an amplified effect. There is a huge amount of specificity in ligand receptor binding. Ligands - Answer Hormones, GF, gases, All first messengers. Must be specific and saturable to a receptor. Receptors/Transducers - Answer Ligand binding domain, enzymatic activity in intracellular domain/protein kinase activity. Can be transmembrane. Sensitivity of a cell is determined by the number and type of cell surface receptor. Intracellular Mediators - Answer Adaptor proteins, docking proteins, GTP binding proteins Effector/Target Protein or Enzyme - Answer Protein
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