NR293 Pharmacology Final Exam Review 2021/2022 Solved 100%

Pharmaceutical Phase 1 - ANSWER-Disintegration of drug form - drug dissolves in body - available for absorption Pharmaceutical Phase 2 - ANSWER-Absorption, distribution, metabolism, excretion Pharmaceutical Phase 3 - ANSWER-Drug-receptor interaction Absorption of furosemide (lasix) - ANSWER-Decreased in HF and renal failure (risk for toxicity) Acts in Loop of Henle blocking absorption of NaCl Distribution of furosemide (lasix) - ANSWER-Crosses placenta and enters breast milk 95% bound to plasma proteins in body Metabolism of furosemide (lasix) - ANSWER-Liver and kidneys, minimal metabolization Excretion of furosemide (lasix) - ANSWER-50% is excreted unchanged (renal) What is an adverse drug event? - ANSWER-Unexpected and non-therapeutic event What do you do in an adverse drug event? - ANSWER-1) Assess patient ABCs 2) Notify prescriber/HCP 3) File incident report Pregnancy Category A - ANSWER-No indication of risk to fetus Pregnancy Category B - ANSWER-No indication of risk to animal fetus, info for humans unavailable Pregnancy Category C - ANSWER-Adverse effects in animal fetus reported, info for humans unavailable Pregnancy Category D - ANSWER-Fetal risk in humans reported; consider risks vs. benefits Pregnancy Category X - ANSWER-Fetal abnormalities reported, NOT used in pregnant women Ibuprofen Pregnancy Category - ANSWER-C up to 30 weeks, D after 30 weeks, acceptable for nursing mothers