ABIM UWORLD-146 Questions with Complete Solutions

ABIM UWORLD-146 Questions with Complete Solutions Diagnosing Mixed Connective Tissue Disease - CORRECT ANSWER Anti-U1-RNP + at least 3 of the following: - Swollen hands or fingers - Myositis or myalgia - Synovitis - Raynaud's phenomenon Drug-induced lupus antibody - CORRECT ANSWER DNA-histone complex (95%) SLE antibody - CORRECT ANSWER ds DNA(97%), Smith Systemic sclerosis antibody - CORRECT ANSWER RNA polymerase II and II Scl-70/anti-topoisomerase I Sjogren's syndrome - CORRECT ANSWER anti-SS-Ro/SS-La (SSa and SSb) Limited scleroderma - CORRECT ANSWER Anti-centromere Polymyositis/Dermatomyositis - CORRECT ANSWER Anti-Jo-1 (Amioacyl-trNA synthetases) anti-SRP anti-Mi-2 Microscopic polyangiitis - CORRECT ANSWER myeloperoxidase Granulomatosis with polyangiitis (Wegener) - CORRECT ANSWER PR3-ANCA (proteinase 3) Most common complication of MCTD leading to increased mortality - CORRECT ANSWER Pulmonary HTN Treatment of MCTD - CORRECT ANSWER Glucocorticoids What is dabigatran? - CORRECT ANSWER direct thrombin inhibitor (Pradaxa) How can A/C be assessed on dabigatran? - CORRECT ANSWER Thrombin time Which dabigatran patients can have urgent/emergent surgery? - CORRECT ANSWER Normal thrombin time (not anticoagulated) What can you give dabigatran patients with elevated thrombin time who need urgent/emerget surgery? - CORRECT ANSWER Idarucizumab (Praxbind) How can A/C be assessed on rivaroxaban/apixaban? - CORRECT ANSWER plasma anti-factor Xa activity Dabigratan patients undergoing elective surgery... how long do they discontinue the med before surgery? - CORRECT ANSWER 48 hours (12 hr half-life)