USMLE Step 1 Drugs Quiz with complete solutions | Latest 2023/2024

USMLE Step 1 Drugs Quiz with complete solutions | Latest 2023/2024 Acebutolol -- B1 (cardioselective) antagonist; Class II antiarrhythmic (beta blocker) Acetazolamide -- Carbonic anhydrase inhibitor Adenosine -- Unclassified Antiarrhythmic (slows conduction through AV node) Albuterol -- B2 agonist Aliskiren -- Renin inhibitor Alprazolam -- Benzo Amantadine -- Blocks attachment, penetration and uncoating of influenza A virus (not used anymore), Antiparkinsonian via block of reuptake/or increased release of DA Amiloride -- K+ sparing diuretic (no anti-androgenic effects) Amiodarone -- Class III antiarrhythmic (K+ channel blocker) Amitriptyline -- TCA Amphetamine -- Indirect Catecholamine agonists. Sympathomimetic amines that promote release of catecholamines (primarily dopamine and norepinephrine) from their storage sites in the presynaptic nerve terminals. A less significant mechanism may include their ability to block the reuptake of catecholamines by competitive inhibition. Aripiprazole -- Atypical antipsychotic - Full Agonist at D3, D4, 5HT2C. Partial Agonist at D2 and 5HT1A, and Antagonist at 5HT2A Atenolol -- B1 (cardioselective) antagonist Atomoxetine -- ADHD med - selective NE reuptake inhibitor Atracurium -- Nondepolarizing neuromuscular blocking agent/skeletal muscle relaxant Atropine -- Muscarinic blocker Benztropine -- Muscarinic blocker Bethanechol -- Direct muscarinic activator Bosentan -- Blocks both ETa and ETb (Endothelin) receptors to treat pulmonary hypertension Bromocriptine -- DA agonist Bupivacaine -- Amide local anesthetic Buprenorphine -- Partial Opioid Agonist Partial mu agonist, weak kappa antagonist. Bupropion -- Antidepressant - Weak DA/NE reuptake blocker MOA not fully understood Buspirone -- Anti-anxiety - 5-HT partial agonist 5-HT1A, 5-HT2, and DA Captopril -- ACE-I Carbamazepine -- Anticonvulsant - Na channel blocker Carbidopa -- AAAD inhibitor Carvedilol -- a1 and B antagonist Chlorpromazine -- Typical antipsychotic - DA Antagonist Cholestyramine -- Resin Binds to Bile to form an insoluble complex, and increases loss of bile acid-bound low density lipoprotein cholesterol Clomipramine -- TCAs Clonidine -- a2 agonist Clozapine -- Atypical antipsychotic Antagonism of the dopamine type 2 (D2) and serotonin type 2A (5-HT2A) receptors. In addition, it acts as an antagonist at alpha-adrenergic, histamine H1, cholinergic, and other dopaminergic and serotonergic receptors Cocaine -- Indirect-acting adrenergic agonist; ester local anesthetic