Nur 294 Drugs: Pharm Exam III

Nur 294 Drugs: Pharm Exam III.• Dabigatran: direct thrombin inhibitor (anticoagulant) o MOA: directly blocks thrombin actions o Indications: non-valvar afib. OR thromboembolic events, given when heparin is inappropriate or history of HIT o Contraindications: internal bleeding, elevated aPTT, mechanical heart valves, caution with renal disease, GI ulcers, recent trauma/surgery o Route: PO o Onset: 30-90 min o DOA: half-life 12-17 hrs. o Adverse effects: bleeding, hypersensitivity, dyspepsia and gastritis o Category: C • Heparin: indirect thrombin inhibitor (anticoagulant) o MOA: indirectly blocks thrombin by activating anti-thrombin III o Indications: MI or stroke, DVT, PE, unstable angina, thrombosis prevention in patients with high risk o Contraindications: active internal bleeding, hemorrhage, bacterial endocarditis, severe HTN, recent trauma or surgery o Route: IVPB, SQ o DOA: 8-12 hrs., half-life of 90min o Onset: IV immediate, SQ 30-60min o Adverse effects: HIT (heparin-induced thrombocytopenia that triggers the immune system and drops platelet count)