NUR-641E Advanced Pathophysiology and Pharmacology for the Nurse Educator|207 questions| with correct answers

Pharmacokinetics CORRECT ANSWER Involves ADME (absorption, distribution, metabolism and elimination). Absorption: absorption from the administration site either directly or indirectly into the blood/plasma. Distribution: reversibly or irreversibly move from the bloodstream into the interstitial and intracellular fluid. Metabolism: bio-transformed via hepatic metabolism or by other tissues. Elimination: lastly, the drug & its metabolites are eliminated from the body The route of administration with the highest bio-availability is CORRECT ANSWER Intravenous; putting entire dose into a patient's vein and bypassing absorption. Intravenous route avoids first-pass metabolism in the liver. rectal administration disadvantages CORRECT ANSWER variable and erratic absorption Steady state (SS) CORRECT ANSWER is usually reached within 4-5 half-lives of a drug The half-life of a drug is defined as CORRECT ANSWER how long it takes for half the drug to be excreted from the body Half-life of a drug CORRECT ANSWER Determines how frequently the drug must be administered