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BMTCN Complete Solutions With Satisfactory Tests Graded A+

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BMTCN Complete Solutions With Satisfactory Tests Graded A+ What type of transplants commonly have PTLD as a secondary malignancy? Correct Answer: Allow HSCT with T-cell depleted graft Therapies associated with therapy-related acute leukemia and MDS Correct Answer: alkylating agents (eg. Cytoxan, cisplatin, melphalan, busulfan, ifos) , radiation, topoisomerase II inhibitors (eg. doxorubicin, etoposide, mitoxantrone) Genetic predispositions that increase risk of primary and secondary cancers Correct Answer: neurofibromatosis type 1, Fanconi anemia Risk factors for PTLD Correct Answer: T-cell depleted graft, mismatched related or unrelated donor. Busulfan, ATG, mAbs, TBI patient w/ primary immunodeficiency, acute or extensive GVHD, EBV Risk factors for secondary solid tumors Correct Answer: younger age at HSCT, TBI, chronic GVHD, increasing time from transplant, infections, genetic predisposition, lifestyle factors Treatment options for PTLD Correct Answer: EBV-specific cytotoxic T cells, mAbs targeted to B cells (rituximab), combination chemotherapy

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