PHARM MIDTERM QUESTIONS AND ANSWERS 2023

Why are most statins recommended to be taken in the evening?  Can cause insomnia  Decreases stomach upset  Cholesterol synthesis increases during the night  Cholesterol synthesis decreases during the night 2. What is the mechanism of action of ezetimibe?  It inhibits the absorption of bile, thus causing the liver to produce bile from cholesterol.*  It decreases the adhesion of cholesterol on the arterial walls.  It inhibits absorption of dietary and biliary cholesterol in the small intestine.  (option cutoff) 3. Which of the following is not an expected adverse effect of Niacin?  Arthralgias  Hyperglycemia  Itching  Flushing 4. Which adverse effects would you monitor for a patient receiving a statin to manage cholesterol levels. Select all that apply.  Gallstone development  Increased serum transaminase levels  Unexplained muscle pain or tenderness *  Nonalcoholic fatty liver disease *  Elevated creatinine kinase (CK) level with muscle pain * 5. Which of the following drug classes should be avoided in peptic ulcer disease?  Avoid diuretics  Avoid NSAIDS  Avoid proton pump inhibitors  Avoid antibiotics 6. Which of the following groups of antibiotics is notable for side effects such as nephrotoxicity and ototoxicity?  Cephalosporins  Beta-lactams  Aminoglycoside  Tetracyclines 7. Which of the following is most likely an intervention for otitis media?  Corticosteroids  Aspirin  Immunoglobulins  Amoxicillin 8. Which of the following medications is a fluoroquinolone antibiotic?  Penicillin  Azithromycin  Amikacin  Ciprofloxacin 9. Which of the following best classifieds aminoglycosides, macrolides, and clindamycin?  mycolic acid synthesis inhibitors  protein synthesis inhibitors  cell wall inhibitors  folic acid synthesis inhibitors 10. Which of the following groups of antibiotics binds to the 50S subunit of the bacterial ribosome and includes drugs such as erythromycin and azithromycin?  macrolides  fluoroquinolones  aminoglycosides  tetracyclines