Chemotherapy Certification with complete solution 2023

Chemotherapy Certification with complete solution 2023Doxorubicin Cardiotoxic TISSUE VESICANT Baseline MUGA and total dose (CONCERN at 550 mg/m2) URINE=RED IF EXTRAVASATION OCCURS= cool/ice + Totect Idamycin Cardiotoxic (cardiomyopathy) Bleomycin AVOID oxygen supplementation Methotrexate Leukovorin decreases cytotoxicity Pemetrexed Vitamin B12 & folic acid supplements to decrease toxicity Fludarabine Immunosuppression Thioguanine Bone Marrow Suppression Stomatitis/Mucositis 5-FU *Stomatitis Bone marrow depression *Diarrhea Mucositis Capeticibine ***Pro-drug that converts 5FU in liver Stomatitis & mucositis Palmar-plantar erythrodysthesias (hand foot syndrome) Cytarabine or Cytosine Arabinoside Cerebellar neurotoxicity Gemcitabine Radiosensitizer DO NOT GIVE W/ RADIATION, except at very low doses Carmustine ***Solvent is alcohol Alcohol sensivity is an issue Mix ONLY in 0.9% NaCl Carboplatin Dose by CALVERT formula Allergic reaction increased from 1-27% in pts receiving 6-7 courses Cisplatin Renal toxicity Kidney protection w/ fluids & sometimes AMIFOSTINE MONITOR MAGNESIUM levels Oxaliplatin NEUROTOXICITY AVOID COLD (neuropathies exacerbated by cold exposure) Dilute with D5W* Cyclophosphamide HEMMORRAGHIC CYSTITIS Blood in urine - fluids (sometimes Mesna) Temazolamide Headache (crosses into CNS)*** Interferons ACUTE: Flu-like Syndrome CHRONIC: Depression- BLACK BOX WARNING Interleukin-2 Flu-like Syndrome Capillary Leak Syndrome Cabazitaxel No PVC bags or tubing! Docetaxel No PVC bags or tubing! Paclitaxel Glass or Polyolefin container. NO PVC container or tubing. 0.22 in-line filter Etoposide Alopecia Hypotension Can cause hypotension w/ rapid infusion Monitor for hypersensitivity reactions Irinotecan EARLY diarrhea - give atropine LATE diarrhea - give Imodium