NURS 615 kylie (1)-Gout Treatment Exam 3 Questions And Answers Graded A.

NURS 615 kylie (1)-Gout Treatment Exam 3 Questions And Answers Graded A. Gout treatment. Decrease alcohol and organ meat, dish and bacon in diet Antigout Drugs: allopurinol (Zyloprim), colchicine, and febuxostat (Uloric) • allopurinol • inhibit synthesis of uric acid by inhibiting xanthine oxidase conversion of hypoxanthine & xanthine to uric acid • prevent flares • monitor renal and liver function tests before treatment • drowsiness/dizziness may occur • Febuxostat: • inhibit synthesis of uric acid by inhibiting xanthine oxidase conversion of hypoxanthine & xanthine to uric acid • prevents flares • risk of gout flare up when starting febuxostat; patient should be concurrently taking NSAID or colchicine for up to 6 months • monitor liver o colchicine  decreases inflammatory response to urate crystal deposits  For acute attacks  Low dose vs. High dose—low dose has better efficacy with less s/e  1.2 mg followed by 0.6mg 1hour later vs 1.3mg followed by 0.6 mg every 4-6 hours 4.8mg total  Colchicine always causes diarrhea, other GI symptoms (upset stomach, nausea, abdominal pain) can be decreased if taken with food  Do not stop abruptly  Decrease dose with hepatic dysfunction  Patient should be educated to recognize and report proximal muscle weakness, myalgia, and neuropathy if taking colchicine. Contact doctor These can be an adverse effect of colchicine and usually resolve within 3-4 weeks of stopping the medication. • Labs to monitor with gout treatment:  Uric acid levels  Allopurinol, colchicine, probenecid, sulfinpyrazone-liver and renal function before and during therapy, BUN, creatinine, & creatinine clearance  Monitor acid-base balance in patients whose urine is being alkalinized Uricosuric agents: probenecid (Benemid) & Sulfinpyrazone (Anturane) • probenecid & sulfinpyrazone inhibit renal tubular reabsorption of urate and therefor increase excretion of uric acid via the kidneys and decrease serum uric acid • sulfinpyrazone also competitively inhibits platelet aggregation, multiple drug interactions • not anti-inflammatory • not for use in acute attacks • Probenecid-CBC-watch for blood dycrasias; patient education re s/s of blood dyscrasia that should be reported *fever, sore throat, fatigue, bruising easily.