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Samenvatting Immunologie: overzicht merkers een cytokines

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Geen samenvatting van het hele vak immunologie, wel een overzicht van alle belangrijkste cytokines en merkers die door verschillende cellen geproduceerd worden en/of tot expressie worden gebracht. Score: 17/20

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IMMUNOLOGIE
CYTOKINES & MERKERS
Academiejaar 2018-2019

Bronnen:
Samenvatting gemaakt a.d.h.v. de lessen en PowerPoint’s van Prof. Dr. Didier Ebo & a.d.h.v. Rijkers,
G.T. & Kroese, F.G.M. (2016). Immunologie. Houten: Bohn Stafleu van Loghum

, Cytokines

Macrofagen

Molecule/cytokine Geproduceerd door Doelwit Effect Andere zaken
IFN-γ NK en Th1 en CTL MF Activatie
IFN-γ NK en Th1 MF Antiviraal
IL 12 MF NK Feedback
IL 1 en 6 MF Hersenen Anorexie, koorts,
slaperigheid…
IL 6 MF Lever Synthese acutefase-
eiwitten
IL1, 6 en TNF-α MF Beenmerg Vrijzetting +
activatie neutro’s &
MF (leukocytose,
thrombocytose en
anemie)
IL 1 en TNF-α MF DC Maturatie DC
IL 8 en IL 17 MF (IL 8) Neutro’s Neutro’s aantrekken
Th17 (IL 17)
TNF-α en IL 1, 6 MF Endotheel Endotheel activeren Gevolg:
vasodilatatie en
adhesiemoleculen
IFN-α en -β MF ≠ Antiviraal

Polymorfonucleaire granulocyten

Molecule/cytokine Geproduceerd door Doelwit Effect Andere zaken
IL 5 / Eosinofielen Positief effect IL 5 blokkeren via
mepolizumab
IL 8 en IL 17 MF (IL 8) Neutro’s Neutro’s aantrekken
Th17 (IL 17)
Complement (C5a) / Neutro’s Acitvatie
en IFN-γ
PAMPS/DAMPS, / MC & baso’s Activatie
complement,…
IgE

ILC’s

Molecule/cytokine Geproduceerd door Doelwit Effect Andere zaken
IFN-γ ILC1 / Tegen IC bacteriën
IL 4, 5, 9 en 13 ILC2 / Parasieten &
wondgenezing
IL 17 en 22, TNF ILC3 / IC bacteriën &
wondgenezing

Document information

Study: Biomedische Wetenschappen
Uploaded on: October 12, 2022
Number of pages: 5
Written in: 2018/2019
Type: Summary

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cytokines
merkers
tabel
tabellen
overzicht
uantwerpen
immunologie
bmw
biomedische
ua
samenvatting

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