Biochemistry - C785 Module 2
carboxyl group Correct Answer: A -COOH group, found in organic acids.
amino group Correct Answer: a chemical group consisting of a nitrogen atom bonded to two hydrogen
atoms
Where are the hydrophobic amino acids found in the protein? Correct Answer: found in the interior of
the protein
What kind of bond connects a positively charged group and a negatively charged group? Correct
Answer: ionic bond
What type of reaction forms a peptide bond? Correct Answer: dehydration synthesis
What type of reactions breaks the peptide bond? Correct Answer: Hydrolysis reaction
Peptide bonds are in what structure? Correct Answer: Primary structure
Hydrogen bonds hold which structure together? Correct Answer: Secondary and tertiary
What amino acids are found on the exterior of the protein? Correct Answer: polar amino acids
Two non-polar amino acids make what kind of interaction? Correct Answer: Hydrophobic interactions
Non-covalent interactions between amino acid R groups Correct Answer: hydrophobic, ionic and
hydrogen bonds
What structure has a disulfide bond that holds together 2 subunits of an enzyme? Correct Answer:
quaternary structure
What structure has an Ionic interactions that hold together 4 different subunits of a protein? Correct
Answer: quaternary structure
What structure has an Ionic interactions that hold together 3 identical polypeptides Correct Answer:
quaternary structure
non polar amino acids Correct Answer: hydrophobic bond, weak strength, heat disrupts the interaction
primary structure of protein Correct Answer: the amino acid sequence of the polypeptide chain
secondary structure of protein Correct Answer: Hydrogen bonds are involved in this level of structure
and the amino and carboxyl groups (backbone) form these bonds
, tertiary structure of protein Correct Answer: hydrogen, ionic and disulfide bonds as well as hydrophobic
interactions
quaternary structure of a protein Correct Answer: 2 or more polypeptides interact to form the protein
Fate of misfolded proteins Correct Answer: aggregation, degradation and refolding
What kind of interaction between misfolded protein leads to aggregation? Correct Answer: hydrophobic
interaction
What kind of proteins take part in the process involving refolding? Correct Answer: chaperones
A diabetic patient is suffering from ketoacidosis has low blood pH. What bond or interaction is most
likely to be disrupted within a patient's hemoglobin? Correct Answer: hydrogen bonds and ionic
interactions
A patient presents with a fever of 110 F. Which bond or interactions is most likely to be disrupted within
a neuronal protein if the fever isn't resolved quickly? Correct Answer: hydrophobic interactions
Frying an egg in a pan changes the egg white color, due to the protein ovalbumin, from translucent to
white. Which bond or interaction is most likely to be disrupted within the ovalbumin? Correct Answer:
hydrophobic interactions
Protein heated to 140F loss of function and denatured Correct Answer: loss of function and denatured
Native protein misfolds and remains misfolded loss of function and aggregated Correct Answer: loss of
function and aggregated
Normally active protein at physiological blood pH, where placed in a solution with a very low pH (less
than 2) loss of function and denatured Correct Answer: loss of function and denatured
Protein is placed in a solution with a very high pH (greater than 10) loss of function and denatured
Correct Answer: loss of function and denatured
Protein is modified by adding a phosphate group either loss or no loss of function Correct Answer: loss
or no loss of function
Composed of amino acids Correct Answer: Proteins, enzymes, cell membrane receptors, antibodies,
DNA polymerase
Enzymes are a Correct Answer: special type of protein, so they are also composed of amino acids
When the hydrophobic leucine (CH3) is replaced by the positively-charged arginine (NH2+), the protein
will misfold because the amino acids belong to different categories. Correct Answer: A missense
mutation in the gene coding for DNA polymerase replaces a leucine in position 44 with an arginine cause
the DNA polymerase to misfold
DNA polymerase is responsible for Correct Answer: synthesizing DNA in the DNA replication proess
carboxyl group Correct Answer: A -COOH group, found in organic acids.
amino group Correct Answer: a chemical group consisting of a nitrogen atom bonded to two hydrogen
atoms
Where are the hydrophobic amino acids found in the protein? Correct Answer: found in the interior of
the protein
What kind of bond connects a positively charged group and a negatively charged group? Correct
Answer: ionic bond
What type of reaction forms a peptide bond? Correct Answer: dehydration synthesis
What type of reactions breaks the peptide bond? Correct Answer: Hydrolysis reaction
Peptide bonds are in what structure? Correct Answer: Primary structure
Hydrogen bonds hold which structure together? Correct Answer: Secondary and tertiary
What amino acids are found on the exterior of the protein? Correct Answer: polar amino acids
Two non-polar amino acids make what kind of interaction? Correct Answer: Hydrophobic interactions
Non-covalent interactions between amino acid R groups Correct Answer: hydrophobic, ionic and
hydrogen bonds
What structure has a disulfide bond that holds together 2 subunits of an enzyme? Correct Answer:
quaternary structure
What structure has an Ionic interactions that hold together 4 different subunits of a protein? Correct
Answer: quaternary structure
What structure has an Ionic interactions that hold together 3 identical polypeptides Correct Answer:
quaternary structure
non polar amino acids Correct Answer: hydrophobic bond, weak strength, heat disrupts the interaction
primary structure of protein Correct Answer: the amino acid sequence of the polypeptide chain
secondary structure of protein Correct Answer: Hydrogen bonds are involved in this level of structure
and the amino and carboxyl groups (backbone) form these bonds
, tertiary structure of protein Correct Answer: hydrogen, ionic and disulfide bonds as well as hydrophobic
interactions
quaternary structure of a protein Correct Answer: 2 or more polypeptides interact to form the protein
Fate of misfolded proteins Correct Answer: aggregation, degradation and refolding
What kind of interaction between misfolded protein leads to aggregation? Correct Answer: hydrophobic
interaction
What kind of proteins take part in the process involving refolding? Correct Answer: chaperones
A diabetic patient is suffering from ketoacidosis has low blood pH. What bond or interaction is most
likely to be disrupted within a patient's hemoglobin? Correct Answer: hydrogen bonds and ionic
interactions
A patient presents with a fever of 110 F. Which bond or interactions is most likely to be disrupted within
a neuronal protein if the fever isn't resolved quickly? Correct Answer: hydrophobic interactions
Frying an egg in a pan changes the egg white color, due to the protein ovalbumin, from translucent to
white. Which bond or interaction is most likely to be disrupted within the ovalbumin? Correct Answer:
hydrophobic interactions
Protein heated to 140F loss of function and denatured Correct Answer: loss of function and denatured
Native protein misfolds and remains misfolded loss of function and aggregated Correct Answer: loss of
function and aggregated
Normally active protein at physiological blood pH, where placed in a solution with a very low pH (less
than 2) loss of function and denatured Correct Answer: loss of function and denatured
Protein is placed in a solution with a very high pH (greater than 10) loss of function and denatured
Correct Answer: loss of function and denatured
Protein is modified by adding a phosphate group either loss or no loss of function Correct Answer: loss
or no loss of function
Composed of amino acids Correct Answer: Proteins, enzymes, cell membrane receptors, antibodies,
DNA polymerase
Enzymes are a Correct Answer: special type of protein, so they are also composed of amino acids
When the hydrophobic leucine (CH3) is replaced by the positively-charged arginine (NH2+), the protein
will misfold because the amino acids belong to different categories. Correct Answer: A missense
mutation in the gene coding for DNA polymerase replaces a leucine in position 44 with an arginine cause
the DNA polymerase to misfold
DNA polymerase is responsible for Correct Answer: synthesizing DNA in the DNA replication proess
