AP Biology Chapter 17 Guided Reading Assignment

AP Biology Chapter 17 Guided Reading Assignment 1. What did Garrod mean by “inborn errors of metabolism?” Garrod was the first to suggest that genes dictate phenotypes through enzymes that catalyze specific chemical reactions in the cell. Garrod postulated that the symptoms of an inherited disease reflect a person’sinability to make a particular enzyme. 2. Describe the Beadle and Tatum experiment with mold in detail – use the diagram below to help. The logic behind both the experiment and the results are critical. Tatum and Beadle where inquiring if individual genes specified the enzymes that function in a biochemical pathway. Working with the mold Neurospora crassa, they isolated mutants that required arginine in their growth medium. Research showed that the mutants fell into three different classes that each was defective in a different gene. This experiment tested there one gene- one enzyme hypothesis and their postulated arginine-synthesizing pathway. In this experiment, they grew their 3 different mutants and four different conditions.