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  • Katholieke Universiteit Leuven (KU Leuven)
  • Farmaceutische Wetenschappen
  • Organische Chemie II (K03B0B)
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Samenvatting herkennende structuren Organische Chemie II (K03B0B)

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2020/2021 Written for academic year
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Katholieke Universiteit Leuven (KU Leuven)
Course
Organische Chemie II (K03B0B)
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samenvatting van de structuren die herkend dienen te worden

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Dopamine

- neurotransmittor voor bewegingscontrole en evenwicht
- tekort bij verlies van neuronale cellen wordt gecompenseerd met L-DOPA (gaat
doorheen BBB). Activiteitsverlies door het monoamine oxidase wordt tegengegaan
door inhibitoren.




SAM

- ( S-Adenosyl methionine )
- in vivo een biologisch methylerend agens
- Noradrenaline als Nu op koolstof van methyl
- S = LG
- vorming van epinephrine (= adrenaline ).
- SN2




Methyltetrahydrofolaat

- methylerend agens.
- Nu op methyl
- Amine = LG
- thymine uit Uracil.
- SN2

, HGPRTase

- Hypoxanthine Guanine Phosphoribosyl Transferase
- SN2-type enzymatische reactie.
- als Nu op de koolstof, gebonden aan 2P
- pyrofosfaat = LG
- inosine monofosfaat
- deficientie geeft mentale retardatie.




Glutathione

- nucleofiel dat ons beschermt tegen elektrofielen die reageren met
proteïnen en DNA.
- S- = LG
- O- = carboxylaat
- Glu-Cys-Gly
- SN2 product is erg polair en makkelijk te excreteren.




Alkylerende agentia :

- Antikanker producten
- adderen alkyl groepen op DNA via SN2.
- Cl- en CH3SO3- = LG.
- 2 leaving groepen resulteert in DNA
crosslinking, een toxisch proces.

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Number of pages
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Subjects

  • organische chemie
  • structuren herkennen

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