PHARM EXAM 2 STUDY GUIDE
Thursday, May 13, 2021 6:34 PM
ANTI-INFLAMMATORY DRUGS
GLUCOCORTICOIDS
- Foundation of asthma therapy
- Does nothing for acute attacks
- Taken daily for long-term control
- Considered the most effective for prophylaxis
○ Used usually with leukotriene modifiers (Singulair)
- Dosing by fixed schedule (not PRN)
- Mechanism of Action
○ Decrease synthesis and release of inflammatory mediators
○ Suppress airy mucous production
○ Decrease edema of airway mucosa caused by beta-2 agonists
- Usually inhaled (can be PO or IV)
○ Inhaled is safer than oral due to systemic side effects
- Adverse Effects
○ Dysphonia
○ Oropharyngeal candidiasis (rinse mouth/use spacer)
○ Bone loss
○ Infection
○ Hyperglycemia
○ Increased appetite
○ Insomnia
○ Adrenal suppression
- Prolonged use = Must be discontinued slowly
Beclomethasone (Inhaled)
- Rinse mouth after use to avoid thrush and vocal changes
Prednisone (oral)
BRONCHODILATORS
- Does not alter the underlying disease process
- Provides symptomatic relief
- Is usually combined with glucocorticoid for long-term suppression of inflammation
- Used for acute episodes
BETA-2 ADRENERGIC AGONISTS
- Used in asthma and COPD
- Interaction: Negated by beta blockers
- Education:
○ Wait 1 minute between puffs of same med
○ Wait 5 minutes between puffs of different meds
○ Bronchodilator before glucocorticoid
Albuterol (SABA) AccuNeb, Proventil HFA, Pro Air HFA, Venntolin HFA
- Used for acute attack
- Fast on, fast off
- Take PRN
ANTICHOLINERGICS
Ipratropium
- Improves lung function by blocking muscarinic receptors in the bronchi
- Administered via inhalation to relieve bronchospasm
Therapeutic effect onset 30 Seconds
- 50% Maximum 3 Minutes
D u ra t i o n
as d ow n l o ad ed by
6 H ou r
2 fr om C
This study source o.com on 11-04-2021 12:42:27 GMT -05:00
w
https://www.coursehero.com/file/95669290/EXAM-2-STUDY-GUIDEpdf/
, - Adverse Effects
○ Dry mouth
○ Hoarseness
○ Pharyngeal irritation
- Patient Education
○ Fluid and hard candy for dry mouth
○ Rinse mouth to reduce taste
INHALED CORTICOSTEROID
Fluticasone
- Rinse mouth after use to avoid thrush and vocal changes
SYMPATHOMIMETIC
Pseudoephedrine
ANTITUSSIVE
Codeine
FOR SEVERE EXACERBATION
Oxygen Relieves hypoxemia
IV Glucocorticoid Reduces airway inflammation
Nebulized High-Dose SABA Relieves airflow obstruction
Nebulized Ipratropium Further reduces obstruction
- Pulmonary Hypertension
○ Affects right side of the heart
○ Arteries and veins harden, increasing BP
○ Causes
▪ COPD, Interstitial lung disease
▪ Scleraderma, Portal hypertension
▪ AIDS, Immune disorders
PROTON PUMP INHIBITORS
Omeprazole
H2 RECEPTOR ANTAGONISTS
Cimetidine
- Take at least 1 hour apart from antacids
OSMOTIC LAXATIVES
Magnesium Hydroxide
- Also used as antacid
SEROTONIN ANTAGONISTS
Ondansetron
- Side Effects
○ Headache
○ Dizziness
○ Fall risk
BULK-FORMING AGENTS
- Take with at least 8 oz of water
Methylcellulose
SURFACTANTS
Docusate Sodium Colace
This study source was downloaded by 100000823822032 from CourseHero.com on 11-04-2021 12:42:27 GMT -
https://www.coursehero.com/file/95669290/EXAM-2-STUDY-
Thursday, May 13, 2021 6:34 PM
ANTI-INFLAMMATORY DRUGS
GLUCOCORTICOIDS
- Foundation of asthma therapy
- Does nothing for acute attacks
- Taken daily for long-term control
- Considered the most effective for prophylaxis
○ Used usually with leukotriene modifiers (Singulair)
- Dosing by fixed schedule (not PRN)
- Mechanism of Action
○ Decrease synthesis and release of inflammatory mediators
○ Suppress airy mucous production
○ Decrease edema of airway mucosa caused by beta-2 agonists
- Usually inhaled (can be PO or IV)
○ Inhaled is safer than oral due to systemic side effects
- Adverse Effects
○ Dysphonia
○ Oropharyngeal candidiasis (rinse mouth/use spacer)
○ Bone loss
○ Infection
○ Hyperglycemia
○ Increased appetite
○ Insomnia
○ Adrenal suppression
- Prolonged use = Must be discontinued slowly
Beclomethasone (Inhaled)
- Rinse mouth after use to avoid thrush and vocal changes
Prednisone (oral)
BRONCHODILATORS
- Does not alter the underlying disease process
- Provides symptomatic relief
- Is usually combined with glucocorticoid for long-term suppression of inflammation
- Used for acute episodes
BETA-2 ADRENERGIC AGONISTS
- Used in asthma and COPD
- Interaction: Negated by beta blockers
- Education:
○ Wait 1 minute between puffs of same med
○ Wait 5 minutes between puffs of different meds
○ Bronchodilator before glucocorticoid
Albuterol (SABA) AccuNeb, Proventil HFA, Pro Air HFA, Venntolin HFA
- Used for acute attack
- Fast on, fast off
- Take PRN
ANTICHOLINERGICS
Ipratropium
- Improves lung function by blocking muscarinic receptors in the bronchi
- Administered via inhalation to relieve bronchospasm
Therapeutic effect onset 30 Seconds
- 50% Maximum 3 Minutes
D u ra t i o n
as d ow n l o ad ed by
6 H ou r
2 fr om C
This study source o.com on 11-04-2021 12:42:27 GMT -05:00
w
https://www.coursehero.com/file/95669290/EXAM-2-STUDY-GUIDEpdf/
, - Adverse Effects
○ Dry mouth
○ Hoarseness
○ Pharyngeal irritation
- Patient Education
○ Fluid and hard candy for dry mouth
○ Rinse mouth to reduce taste
INHALED CORTICOSTEROID
Fluticasone
- Rinse mouth after use to avoid thrush and vocal changes
SYMPATHOMIMETIC
Pseudoephedrine
ANTITUSSIVE
Codeine
FOR SEVERE EXACERBATION
Oxygen Relieves hypoxemia
IV Glucocorticoid Reduces airway inflammation
Nebulized High-Dose SABA Relieves airflow obstruction
Nebulized Ipratropium Further reduces obstruction
- Pulmonary Hypertension
○ Affects right side of the heart
○ Arteries and veins harden, increasing BP
○ Causes
▪ COPD, Interstitial lung disease
▪ Scleraderma, Portal hypertension
▪ AIDS, Immune disorders
PROTON PUMP INHIBITORS
Omeprazole
H2 RECEPTOR ANTAGONISTS
Cimetidine
- Take at least 1 hour apart from antacids
OSMOTIC LAXATIVES
Magnesium Hydroxide
- Also used as antacid
SEROTONIN ANTAGONISTS
Ondansetron
- Side Effects
○ Headache
○ Dizziness
○ Fall risk
BULK-FORMING AGENTS
- Take with at least 8 oz of water
Methylcellulose
SURFACTANTS
Docusate Sodium Colace
This study source was downloaded by 100000823822032 from CourseHero.com on 11-04-2021 12:42:27 GMT -
https://www.coursehero.com/file/95669290/EXAM-2-STUDY-
