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NURS 8024 Pharmacology Exam 1 & Study Guide NURS 8024
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NURS 8024 Pharmacology Exam 1 & Study Guide NURS 8024
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Pharmacology for APNs Study GuideUnderstand the following concepts:
Pharmacokinetics / Pharmacodynamics- you do NOT have to do any calculations!
· Define and understand the concepts of: pharmacokinetics,
pharmacodynamics, pharmacology, pharmacotherapeutics, toxicology, legend
drug vs OTC drug
Pharmacokinetics- the actions of the body on the drug. Pharmacokinetic process
governs the absorption, distribution, and elimination of drugs. Katzung pg 5
Pharmacodynamic-the actions of the drug on the body. Katzung pg 5
Pharmacology- the study of substances that interact with living systems through
chemical processes. These interactions usually occur by binding of the substance to
regulatory molecules and activating or inhibiting normal body processes. These
substances may be chemicals administered to achieve a beneficial therapeutic effect on
some process within the patient or for their toxic effects on regulatory processes in
parasites infecting the patient. Katzung pg 1
Pharmacotherapeutics- therapeutic uses and effects of drugs.
Toxicology- is the branch of pharmacology that deals with the undesirable effects of
chemicals on living systems. Katzung pg 1
All substances have the potential for toxicity.
Legend drug vs OTC drug
Legend drug- is a drug, by law, can be obtained only by prescription.
OTC drug- sold directly to consumer without prescription.
· Understand the different ways drugs are classified- By sources- (derived from
plant – chemical- animal), chemical structure & receptor type (beta- agonists,
calcium channel antagonists etc.) pharmacotherapeutic category/classification
(antihypertensives, antimicrobials etc.
· Pharmacokinetics: understand concepts of Absorption, Distribution,
Metabolism, Elimination
Absorption- Entry of pharmacologic agents into plasma.
Distribution- agents leave bloodstream and distribute to interstitial and intracellular
fluids.
Metabolism- Agent must be metabolized via liver, kidney or other tissue.
Elimination- Agent metabolites must be eliminated from the body (urine, bile, feces.)
-powerpoint
· Understand concepts of pharmacodynamics - Physiologic effect, Mechanism
of action-
, Drug concentration at site of action → pharmacologic effect → clinical response →
effectiveness or toxicity.
· Know the what factors impact drug absorption
Factors that affect drug absorption may be lack of absorption from the gut. Other drugs
are either too hydrophilic or too lipophilic to be absorbed easily, and their low
bioavailability is also doe to incomplete absorption. If too hydrophilic, the drug cannot
cross the lipid cell membrane; if too lipophilic, the drug is not soluble enough to cross
the water layer adjacent to the cell. Drugs may not be absorbed because of a reverse
transporter associated with P-glycoprtein. This process actively pumps drugs out of gut
wall cell back into gut lumen. Inhibition of P-glycoprotein and gut wall metabolism, ex
grapefruit juice, may be associated with substantially increase drug absorption. Katzung
pg 47
Factors influencing GI absorption
Blood flow, intestinal blood flow > stomach blood flow.
pH, especially with H2 receptor blocker or proton pump inhibitors (PPI).
Intestinal surface area (microvilli), 1000x more than stomach.
Contact time with absorptive surface; Variables, rapid vs slow GI transport,
Parasympathetic input- increase rate of gastric emptying, Sympathetic
input- delay gastric emptying, food→ delay absorption. Power point
· Concept of bioavailability - relationship between drug route and
bioavailabilty
Bioavailability is defined as the fraction of unchanged drug reaching the systemic
circulation following administration by any route. For an IV dose, bioavailability is
assumed to be equal to unity, 100%. For PO route bioavailability is less than 100% for
two reasons- incomplete extent of absorption across the gut wall and first-pass
elimination by the liver. Katzung pg 47
· What are the physiologic variables in absorption and distribution
· Know the chemical properties of drugs that affect absorption and
distribution
Chemical properties
Solubility, hydrophilic (lipophobic), or lipophilic (hydrophobic).
Chemical nature- pH and pKa
Molecular weight
Partition coefficient - the ratio of lipid solubility to aqueous solubility. The higher the
partition coefficient, the more membrane soluble is the substance. Powerpoint
· Concept of volume of distribution (Vd)
Hypothetical volume of fluid into which a drug is dispersed. Volume of distribution
relates the amount of drug in the body to the concentration of drug in blood or plasma.
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