GNUR 294 EXAM III
Pharmacotherapy of Dyslipidemia
Lipids are the culprit that help increase the levels of plaque inside the walls
Three types of lipids that the drugs are going to effect
LDL- “bad”, forms the plaque in the vessel walls
HDL- remove LDL from the bloodstream to be metabolized by the liver
Want LDL levels to be low, HDL to be high, the higher the better because the
lower LDL
VLDLs- triglycerides, they are closely tied to carbohydrate metabolism
One or more of these combinations of these drugs
TLCs- therapeutic lifestyle changes
Foods with LDLs- saturated fats (dairy products, meat products, animal fats)
If patients have risk factors for heart disease, need to make sure lipid levels
are in normal range
Nicotine is thought to increase the inflammation
Since the liver metabolizes the cholesterol, the gene that controls metabolism
is defective, that patient will have high LDLs, won’t change no matter their
diet/life style changes
HMG-CoA reductaste- stop the liver from it’s normal metabolism, need
cholesterol in our diets. Negative feedback- if cholesterol levels drop, the
liver will produce more, if it rises lets all the enzymes take care of it. Inhibits
enzymes. In doing that the liver it makes more receptors to reduce the LDL
Rarely will see just one of these given
Pharmacotherapy of Dyslipidemia
Lipids are the culprit that help increase the levels of plaque inside the walls
Three types of lipids that the drugs are going to effect
LDL- “bad”, forms the plaque in the vessel walls
HDL- remove LDL from the bloodstream to be metabolized by the liver
Want LDL levels to be low, HDL to be high, the higher the better because the
lower LDL
VLDLs- triglycerides, they are closely tied to carbohydrate metabolism
One or more of these combinations of these drugs
TLCs- therapeutic lifestyle changes
Foods with LDLs- saturated fats (dairy products, meat products, animal fats)
If patients have risk factors for heart disease, need to make sure lipid levels
are in normal range
Nicotine is thought to increase the inflammation
Since the liver metabolizes the cholesterol, the gene that controls metabolism
is defective, that patient will have high LDLs, won’t change no matter their
diet/life style changes
HMG-CoA reductaste- stop the liver from it’s normal metabolism, need
cholesterol in our diets. Negative feedback- if cholesterol levels drop, the
liver will produce more, if it rises lets all the enzymes take care of it. Inhibits
enzymes. In doing that the liver it makes more receptors to reduce the LDL
Rarely will see just one of these given
