BIO 340 - Unit 4 Questions with Verified Correct
Answers
BCR or TCR: bind to peptide fragments presented on MHC proteins
TCR
BCR or TCR: bind directly to soluble or particulate antigens
BCR
BCR or TCR: successful engagement empowers the responding lymphocyte to undergo
clonal expansion
both
BCR or TCR: can inspect antigens that are largely confined within cells
TCR
BCR or TCR: respond to peptide and carbohydrate antigens
BCR
BCR or TCR: respond ot peptides only
TCR
BCR or TCR: important antigen recognition receptor for the adaptive immune response
both
BCR or TCR: made in almost infinite varieties
both
, BCR or TCR: single type of receptor on each cell
both
what is the difference between a secreted antibody and a membrane associated form of Ig?
membrane associated form has hydrophobic anchor sequence that is inserted into the membrane
the primary RNA transcripts undergoes ___ to form either the mRNA that produces the
transmembrane Ig or the mRNA that produces the secreted Ig.
alternative RNA splicing
what part of a membrane bound Ig is not the heavy or light chain?
Ig(beta) and Ig(alpha)
what is the point of Ig(beta) and Ig(alpha)?
have cytoplasmic tails that function in signal transduction once the Ig binds antigen
cross linking of the BCR by antigen leads to ____ within the cytoplasmic tails of Ig(beta)
and Ig(alpha) by kinases associated with the BCR.
phosphorylation of tyrosines
what does phosphorylation of tyrosine on tails of Ig(beta) and Ig(alpha) creates
binding sites for Syk(protein kinase)
B-cells require __ to become activated.
1. during antigen binding, B-cell co-receptor complex (ie complement on pathogen surface)
2. helper T cell binds to B cell (CD40L ligand)
Answers
BCR or TCR: bind to peptide fragments presented on MHC proteins
TCR
BCR or TCR: bind directly to soluble or particulate antigens
BCR
BCR or TCR: successful engagement empowers the responding lymphocyte to undergo
clonal expansion
both
BCR or TCR: can inspect antigens that are largely confined within cells
TCR
BCR or TCR: respond to peptide and carbohydrate antigens
BCR
BCR or TCR: respond ot peptides only
TCR
BCR or TCR: important antigen recognition receptor for the adaptive immune response
both
BCR or TCR: made in almost infinite varieties
both
, BCR or TCR: single type of receptor on each cell
both
what is the difference between a secreted antibody and a membrane associated form of Ig?
membrane associated form has hydrophobic anchor sequence that is inserted into the membrane
the primary RNA transcripts undergoes ___ to form either the mRNA that produces the
transmembrane Ig or the mRNA that produces the secreted Ig.
alternative RNA splicing
what part of a membrane bound Ig is not the heavy or light chain?
Ig(beta) and Ig(alpha)
what is the point of Ig(beta) and Ig(alpha)?
have cytoplasmic tails that function in signal transduction once the Ig binds antigen
cross linking of the BCR by antigen leads to ____ within the cytoplasmic tails of Ig(beta)
and Ig(alpha) by kinases associated with the BCR.
phosphorylation of tyrosines
what does phosphorylation of tyrosine on tails of Ig(beta) and Ig(alpha) creates
binding sites for Syk(protein kinase)
B-cells require __ to become activated.
1. during antigen binding, B-cell co-receptor complex (ie complement on pathogen surface)
2. helper T cell binds to B cell (CD40L ligand)
