NURS 5334 ADVANCED
PHARMACOLOGY TEST 2 COMPLETE
ANSWERS GRADED A+
◉ Absorption
Answer: Enteral route involves the GI system (oral)
Parenteral route = IV, IM
Transdermal = through the skin
Respiratory = droplet, inhalation
◉ Distribution
Answer: Amount of drug in the body divided by the plasma drug
concentration.
◉ Factors effecting distribution
Answer: Blood flow, lipid solubility, molecular size of the drug,
plasma proteins (very important)
◉ Volume of distribution
Answer: Vd = amount of drug in the body divided by the amount
of drug in the plasma divided by bioavailability.
◉ Bioavailability
, Answer: How much drug makes it into the system. Must account
for absorption and extraction.
◉ Extraction
Answer: How much of the drugs bioavailability can be used by the
body.
◉ **IV route dosing (parenteral)
Answer: Goes directly to the body. Results in 100% bioavailability.
Decreasing first pass effect, decreasing absorption limitations,
extractions...
By passes absorption and extraction.
◉ Loading dose
Answer: [Peak] concentration X Vd divided by bioavailability
◉ Maintenance dose
Answer: [Peak] X Clearance divided by bioavailability
◉ Clearance is affected by
Answer: Kidney function
◉ **If a patient has kidney disease you would
Answer: Decrease your maintenance dose; loading dose stays the
same (doesn't affect clearance)
PHARMACOLOGY TEST 2 COMPLETE
ANSWERS GRADED A+
◉ Absorption
Answer: Enteral route involves the GI system (oral)
Parenteral route = IV, IM
Transdermal = through the skin
Respiratory = droplet, inhalation
◉ Distribution
Answer: Amount of drug in the body divided by the plasma drug
concentration.
◉ Factors effecting distribution
Answer: Blood flow, lipid solubility, molecular size of the drug,
plasma proteins (very important)
◉ Volume of distribution
Answer: Vd = amount of drug in the body divided by the amount
of drug in the plasma divided by bioavailability.
◉ Bioavailability
, Answer: How much drug makes it into the system. Must account
for absorption and extraction.
◉ Extraction
Answer: How much of the drugs bioavailability can be used by the
body.
◉ **IV route dosing (parenteral)
Answer: Goes directly to the body. Results in 100% bioavailability.
Decreasing first pass effect, decreasing absorption limitations,
extractions...
By passes absorption and extraction.
◉ Loading dose
Answer: [Peak] concentration X Vd divided by bioavailability
◉ Maintenance dose
Answer: [Peak] X Clearance divided by bioavailability
◉ Clearance is affected by
Answer: Kidney function
◉ **If a patient has kidney disease you would
Answer: Decrease your maintenance dose; loading dose stays the
same (doesn't affect clearance)
