NU 578 Unit 4 Gastrointestinal Pharmacology Exam | 175
Verified Questions & Answers | Herzing University Nursing |
Instant Download
Q1. Why should bisacodyl enteric-coated tablets not be taken with milk or antacids?
A. Milk and antacids dissolve enteric coating early causing gastric irritation cramping and reduced efficacy in
colon
B. Milk increases bisacodyl absorption dangerously
C. Milk is required to activate bisacodyl
D. No interaction with milk or antacids
Correct Answer: A. Milk and antacids dissolve enteric coating early causing gastric irritation cramping
and reduced efficacy in colon
Rationale: Enteric coating needs intact to colon; milk/antacids dissolve early gastric irritation.
Q2. A patient with GERD and asthma on theophylline is prescribed cimetidine. What interaction
occurs?
A. Theophylline increases cimetidine levels
B. Cimetidine inhibits CYP1A2 raising theophylline levels causing toxicity seizures arrhythmias
C. No interaction cimetidine theophylline
D. Cimetidine lowers theophylline levels
Correct Answer: B. Cimetidine inhibits CYP1A2 raising theophylline levels causing toxicity seizures
arrhythmias
Rationale: Cimetidine CYP1A2 inhibitor raises theophylline toxicity seizures arrhythmias.
Q3. Supplemental GI question 148: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. Lie flat immediately after meals to help GERD
B. No dietary measures needed GERD
C. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
D. Increase high-fat spicy meals to reduce GERD
Correct Answer: C. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Q4. Supplemental GI question 133: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. No dietary measures needed GERD
B. Increase high-fat spicy meals to reduce GERD
C. Lie flat immediately after meals to help GERD
D. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
Correct Answer: D. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Page 1 | NU 578 GI Pharm V1 Perfect
,
Q5. Why must mineral oil not be taken with docusate?
A. Docusate increases mineral oil absorption causing systemic lipid granulomas toxicity
B. Combination cures constipation faster safely
C. Docusate decreases mineral oil efficacy
D. No interaction mineral oil docusate
Correct Answer: A. Docusate increases mineral oil absorption causing systemic lipid granulomas toxicity
Rationale: Docusate increases mineral oil systemic absorption lipid granulomas.
Q6. Supplemental GI question 158: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. Increase high-fat spicy meals to reduce GERD
B. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
C. Lie flat immediately after meals to help GERD
D. No dietary measures needed GERD
Correct Answer: B. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Q7. What is the mechanism of eluxadoline for IBS-D?
A. Bulk-forming
B. 5-HT3 antagonist
C. Mixed mu-opioid receptor agonist delta antagonist kappa agonist slows transit reduces pain but pancreatitis
risk in patients without gallbladder or heavy alcohol
D. Pure mu antagonist
Correct Answer: C. Mixed mu-opioid receptor agonist delta antagonist kappa agonist slows transit
reduces pain but pancreatitis risk in patients without gallbladder or heavy alcohol
Rationale: Eluxadoline mixed mu agonist delta antagonist kappa agonist IBS-D pancreatitis risk no gallbladder alcohol.
Q8. What is the therapeutic use of activated charcoal beyond overdose?
A. Antibiotic
B. Increases gas production
C. No use beyond overdose
D. Adsorbs gas toxins reduces flatulence but also adsorbs medications separate 2-3 hours
Correct Answer: D. Adsorbs gas toxins reduces flatulence but also adsorbs medications separate 2-3
hours
Rationale: Adsorbs gas toxins flatulence adsorbs meds separate 2-3h.
Q9. What is the purpose of testing H pylori stool antigen after treatment?
A. Confirms eradication 4 weeks after completing antibiotics and 2 weeks off PPI to avoid false negative
B. Test immediately after antibiotics
C. Test while still on PPI
D. No testing needed after treatment
Correct Answer: A. Confirms eradication 4 weeks after completing antibiotics and 2 weeks off PPI to
avoid false negative
Rationale: Confirm eradication 4 weeks after antibiotics 2 weeks off PPI avoid false negative.
Q10. How does naldemedine treat opioid-induced constipation without reducing analgesia?
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,
A. Crosses BBB blocks central analgesia
B. PAMORA peripherally acting mu-opioid receptor antagonist does not cross BBB preserves central analgesia
C. Bulk-forming only
D. Stimulant laxative only
Correct Answer: B. PAMORA peripherally acting mu-opioid receptor antagonist does not cross BBB
preserves central analgesia
Rationale: PAMORA peripheral mu antagonist no BBB preserves analgesia.
Q11. Supplemental GI question 166: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. Lie flat immediately after meals to help GERD
B. No dietary measures needed GERD
C. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
D. Increase high-fat spicy meals to reduce GERD
Correct Answer: C. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Q12. What is the therapeutic goal of antiemetic therapy in chemotherapy?
A. Cure cancer antiemetics
B. Only treat after vomiting starts
C. No goal antiemetic therapy
D. Prevent anticipatory acute and delayed nausea vomiting improve quality life maintain chemotherapy adherence
Correct Answer: D. Prevent anticipatory acute and delayed nausea vomiting improve quality life maintain
chemotherapy adherence
Rationale: Prevent anticipatory acute delayed improve adherence.
Q13. Supplemental GI question 146: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
B. No dietary measures needed GERD
C. Increase high-fat spicy meals to reduce GERD
D. Lie flat immediately after meals to help GERD
Correct Answer: A. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Q14. How does ondansetron cause constipation?
A. Only diarrhea ondansetron
B. 5-HT3 blockade slows colonic transit
C. No bowel effects ondansetron
D. 5-HT3 blockade increases motility
Correct Answer: B. 5-HT3 blockade slows colonic transit
Rationale: 5-HT3 blockade slows transit constipation.
Q15. A patient receiving chemotherapy with highly emetogenic cisplatin asks why ondansetron is
combined with dexamethasone and aprepitant. What is the rationale?
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,
A. Combination reduces cost of antiemetics
B. Dexamethasone is used to increase cisplatin efficacy
C. Combination blocks multiple emetic pathways 5-HT3, NK1, and inflammatory mediators for superior prevention
D. Ondansetron alone is ineffective for any chemotherapy
Correct Answer: C. Combination blocks multiple emetic pathways 5-HT3, NK1, and inflammatory
mediators for superior prevention
Rationale: Highly emetogenic chemo needs triple therapy 5-HT3 + NK1 + steroid to block serotonin, substance P,
inflammation.
Q16. Supplemental GI question 156: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. Lie flat immediately after meals to help GERD
B. No dietary measures needed GERD
C. Increase high-fat spicy meals to reduce GERD
D. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
Correct Answer: D. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Q17. A patient receiving lactulose for hepatic encephalopathy has 6 watery stools per day. What is the
nursing action?
A. Hold dose and notify provider, goal 2-3 soft stools daily, overuse causes dehydration electrolyte imbalance
hypernatremia
B. Continue same dose regardless stools
C. Lactulose ineffective if diarrhea occurs
D. Increase dose to cause more diarrhea
Correct Answer: A. Hold dose and notify provider, goal 2-3 soft stools daily, overuse causes dehydration
electrolyte imbalance hypernatremia
Rationale: Lactulose goal 2-3 soft stools ammonia clearance; excessive diarrhea dehydration hypernatremia hold notify.
Q18. Supplemental GI question 142: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. Lie flat immediately after meals to help GERD
B. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
C. No dietary measures needed GERD
D. Increase high-fat spicy meals to reduce GERD
Correct Answer: B. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Q19. A patient with IBS-C is prescribed linaclotide. How does it work?
A. Bulk-forming fiber
B. Opioid agonist slows transit
C. Guanylate cyclase-C agonist increases cGMP increasing fluid secretion and transit, also decreases visceral
pain
D. Chloride channel blocker
Page 4 | NU 578 GI Pharm V1 Perfect
Verified Questions & Answers | Herzing University Nursing |
Instant Download
Q1. Why should bisacodyl enteric-coated tablets not be taken with milk or antacids?
A. Milk and antacids dissolve enteric coating early causing gastric irritation cramping and reduced efficacy in
colon
B. Milk increases bisacodyl absorption dangerously
C. Milk is required to activate bisacodyl
D. No interaction with milk or antacids
Correct Answer: A. Milk and antacids dissolve enteric coating early causing gastric irritation cramping
and reduced efficacy in colon
Rationale: Enteric coating needs intact to colon; milk/antacids dissolve early gastric irritation.
Q2. A patient with GERD and asthma on theophylline is prescribed cimetidine. What interaction
occurs?
A. Theophylline increases cimetidine levels
B. Cimetidine inhibits CYP1A2 raising theophylline levels causing toxicity seizures arrhythmias
C. No interaction cimetidine theophylline
D. Cimetidine lowers theophylline levels
Correct Answer: B. Cimetidine inhibits CYP1A2 raising theophylline levels causing toxicity seizures
arrhythmias
Rationale: Cimetidine CYP1A2 inhibitor raises theophylline toxicity seizures arrhythmias.
Q3. Supplemental GI question 148: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. Lie flat immediately after meals to help GERD
B. No dietary measures needed GERD
C. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
D. Increase high-fat spicy meals to reduce GERD
Correct Answer: C. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Q4. Supplemental GI question 133: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. No dietary measures needed GERD
B. Increase high-fat spicy meals to reduce GERD
C. Lie flat immediately after meals to help GERD
D. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
Correct Answer: D. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Page 1 | NU 578 GI Pharm V1 Perfect
,
Q5. Why must mineral oil not be taken with docusate?
A. Docusate increases mineral oil absorption causing systemic lipid granulomas toxicity
B. Combination cures constipation faster safely
C. Docusate decreases mineral oil efficacy
D. No interaction mineral oil docusate
Correct Answer: A. Docusate increases mineral oil absorption causing systemic lipid granulomas toxicity
Rationale: Docusate increases mineral oil systemic absorption lipid granulomas.
Q6. Supplemental GI question 158: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. Increase high-fat spicy meals to reduce GERD
B. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
C. Lie flat immediately after meals to help GERD
D. No dietary measures needed GERD
Correct Answer: B. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Q7. What is the mechanism of eluxadoline for IBS-D?
A. Bulk-forming
B. 5-HT3 antagonist
C. Mixed mu-opioid receptor agonist delta antagonist kappa agonist slows transit reduces pain but pancreatitis
risk in patients without gallbladder or heavy alcohol
D. Pure mu antagonist
Correct Answer: C. Mixed mu-opioid receptor agonist delta antagonist kappa agonist slows transit
reduces pain but pancreatitis risk in patients without gallbladder or heavy alcohol
Rationale: Eluxadoline mixed mu agonist delta antagonist kappa agonist IBS-D pancreatitis risk no gallbladder alcohol.
Q8. What is the therapeutic use of activated charcoal beyond overdose?
A. Antibiotic
B. Increases gas production
C. No use beyond overdose
D. Adsorbs gas toxins reduces flatulence but also adsorbs medications separate 2-3 hours
Correct Answer: D. Adsorbs gas toxins reduces flatulence but also adsorbs medications separate 2-3
hours
Rationale: Adsorbs gas toxins flatulence adsorbs meds separate 2-3h.
Q9. What is the purpose of testing H pylori stool antigen after treatment?
A. Confirms eradication 4 weeks after completing antibiotics and 2 weeks off PPI to avoid false negative
B. Test immediately after antibiotics
C. Test while still on PPI
D. No testing needed after treatment
Correct Answer: A. Confirms eradication 4 weeks after completing antibiotics and 2 weeks off PPI to
avoid false negative
Rationale: Confirm eradication 4 weeks after antibiotics 2 weeks off PPI avoid false negative.
Q10. How does naldemedine treat opioid-induced constipation without reducing analgesia?
Page 2 | NU 578 GI Pharm V1 Perfect
,
A. Crosses BBB blocks central analgesia
B. PAMORA peripherally acting mu-opioid receptor antagonist does not cross BBB preserves central analgesia
C. Bulk-forming only
D. Stimulant laxative only
Correct Answer: B. PAMORA peripherally acting mu-opioid receptor antagonist does not cross BBB
preserves central analgesia
Rationale: PAMORA peripheral mu antagonist no BBB preserves analgesia.
Q11. Supplemental GI question 166: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. Lie flat immediately after meals to help GERD
B. No dietary measures needed GERD
C. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
D. Increase high-fat spicy meals to reduce GERD
Correct Answer: C. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Q12. What is the therapeutic goal of antiemetic therapy in chemotherapy?
A. Cure cancer antiemetics
B. Only treat after vomiting starts
C. No goal antiemetic therapy
D. Prevent anticipatory acute and delayed nausea vomiting improve quality life maintain chemotherapy adherence
Correct Answer: D. Prevent anticipatory acute and delayed nausea vomiting improve quality life maintain
chemotherapy adherence
Rationale: Prevent anticipatory acute delayed improve adherence.
Q13. Supplemental GI question 146: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
B. No dietary measures needed GERD
C. Increase high-fat spicy meals to reduce GERD
D. Lie flat immediately after meals to help GERD
Correct Answer: A. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Q14. How does ondansetron cause constipation?
A. Only diarrhea ondansetron
B. 5-HT3 blockade slows colonic transit
C. No bowel effects ondansetron
D. 5-HT3 blockade increases motility
Correct Answer: B. 5-HT3 blockade slows colonic transit
Rationale: 5-HT3 blockade slows transit constipation.
Q15. A patient receiving chemotherapy with highly emetogenic cisplatin asks why ondansetron is
combined with dexamethasone and aprepitant. What is the rationale?
Page 3 | NU 578 GI Pharm V1 Perfect
,
A. Combination reduces cost of antiemetics
B. Dexamethasone is used to increase cisplatin efficacy
C. Combination blocks multiple emetic pathways 5-HT3, NK1, and inflammatory mediators for superior prevention
D. Ondansetron alone is ineffective for any chemotherapy
Correct Answer: C. Combination blocks multiple emetic pathways 5-HT3, NK1, and inflammatory
mediators for superior prevention
Rationale: Highly emetogenic chemo needs triple therapy 5-HT3 + NK1 + steroid to block serotonin, substance P,
inflammation.
Q16. Supplemental GI question 156: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. Lie flat immediately after meals to help GERD
B. No dietary measures needed GERD
C. Increase high-fat spicy meals to reduce GERD
D. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
Correct Answer: D. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Q17. A patient receiving lactulose for hepatic encephalopathy has 6 watery stools per day. What is the
nursing action?
A. Hold dose and notify provider, goal 2-3 soft stools daily, overuse causes dehydration electrolyte imbalance
hypernatremia
B. Continue same dose regardless stools
C. Lactulose ineffective if diarrhea occurs
D. Increase dose to cause more diarrhea
Correct Answer: A. Hold dose and notify provider, goal 2-3 soft stools daily, overuse causes dehydration
electrolyte imbalance hypernatremia
Rationale: Lactulose goal 2-3 soft stools ammonia clearance; excessive diarrhea dehydration hypernatremia hold notify.
Q18. Supplemental GI question 142: What dietary measure helps reduce GERD symptoms alongside
pharmacologic therapy?
A. Lie flat immediately after meals to help GERD
B. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight loss, small frequent meals
C. No dietary measures needed GERD
D. Increase high-fat spicy meals to reduce GERD
Correct Answer: B. Elevate head of bed 6-8 inches, avoid late meals, trigger foods, tight clothing, weight
loss, small frequent meals
Rationale: Elevate HOB 6-8 in avoid late meals trigger foods tight clothing weight loss small meals helps GERD.
Q19. A patient with IBS-C is prescribed linaclotide. How does it work?
A. Bulk-forming fiber
B. Opioid agonist slows transit
C. Guanylate cyclase-C agonist increases cGMP increasing fluid secretion and transit, also decreases visceral
pain
D. Chloride channel blocker
Page 4 | NU 578 GI Pharm V1 Perfect
