NR 293 PHARMACOLOGY EXAM 1 CHAMBERLAIN |
2026/2027 STUDY GUIDE, PRACTICE QUESTIONS &
ANSWERS
1. What is the MOA of fluoroquinolones:
Inhibition of helicase
Inhibition of DNA gyrase
Activation of DNA gyrase
Activation of helicase
2. What is the expected infusion-related reaction when administering
amphotericin B?
Rash and itching
Fever, chills, muscle pain, and nausea
Headache and dizziness
Shortness of breath and chest pain
3. Nai is teaching his 1,000,000th pharm group study session and asks a student
to describe clindamycin's MOA. The student says:
Inhibits protein synthesis by interfering with transpeptidation by
blocking the P-site of the 50s ribosome
Binds to the 30s subunit of the ribosome
Disrupts synthesis of peptidoglycan polymer strands
Unknown MOA
4. What is one common adverse effect associated with the use of tetracyclines?
Drowsiness
, Constipation
Photosensitivity
Nausea
5. Which of the following best describes the mechanism of action of ribavirin?
Inhibiting viral integration into genomic DNA
Preventing viral entry into target cells
Inhibiting viral protease activity
Interfering with the duplication of viral genetic material
Preventing uncoating of the virus
6. In a clinical scenario where a patient has a severe penicillin allergy, which
antibiotic class would be most appropriate to prescribe for a Gram-negative
bacterial infection?
Penicillins
Tetracyclines
Cephalosporins
Monobactams
7. Describe the potential adverse effects of Clindamycin and their implications
for patient care.
Clindamycin is safe and has no known adverse effects.
Clindamycin primarily affects the liver and kidneys without
gastrointestinal effects.
Clindamycin can cause diarrhea and colitis, which may lead to
serious gastrointestinal issues in patients.
, Clindamycin is only effective for skin infections and has no adverse
effects.
8. A nurse is preparing to administer medication to a patient but realizes they
are unsure about the patient's allergies. Which of the 9 rights of medication
administration is most directly impacted by this uncertainty?
Right patient
Right dose
Right medication
Right time
9. A nurse is caring for a patient prescribed a carbapenem antibiotic. What is the
primary indication for the use of carbapenems?
Prevention of parasitic infections.
Treatment of viral infections.
Targeted therapy for fungal infections.
Broad-spectrum coverage for life-threatening, resistant infections.
10. Aminoglycosides are often used in combination with other antibiotics, such
as beta-lactams or vancomycin, in the treatment of various infections
because the combined effect of the two antibiotics is greater than that of
either drug alone. The nurse is reviewing the medication orders for a patient
who will be receiving gentamicin therapy. Which other medication or
medication class, if ordered, would be a potential interaction concern?
Loop diuretics
Phenytoin
Calcium channel blockers
, Proton pump inhibitors
11. After an infusion of colistimethate (Coly-Mycin), the nurse will report to the
provider if the pt complains of which adverse effect?
Upset stomach
Insomnia
Vertigo
Dizziness
Numbness
12. If a patient is taking drug A, an enzyme inhibitor, and experiences increased
side effects from drug B, what should the nurse consider regarding the
patient's medication regimen?
Drug B should be discontinued immediately.
Drug A should be increased to counteract the effects.
No changes are necessary in the medication regimen.
The dosage of drug B may need to be adjusted.
13. Most common adverse effect associated with clindamycin
Diarrhea
Ototoxicity
Visual disturbances
QT prolongation
14. Quinolones work by...
Lysing the plasma membrane
2026/2027 STUDY GUIDE, PRACTICE QUESTIONS &
ANSWERS
1. What is the MOA of fluoroquinolones:
Inhibition of helicase
Inhibition of DNA gyrase
Activation of DNA gyrase
Activation of helicase
2. What is the expected infusion-related reaction when administering
amphotericin B?
Rash and itching
Fever, chills, muscle pain, and nausea
Headache and dizziness
Shortness of breath and chest pain
3. Nai is teaching his 1,000,000th pharm group study session and asks a student
to describe clindamycin's MOA. The student says:
Inhibits protein synthesis by interfering with transpeptidation by
blocking the P-site of the 50s ribosome
Binds to the 30s subunit of the ribosome
Disrupts synthesis of peptidoglycan polymer strands
Unknown MOA
4. What is one common adverse effect associated with the use of tetracyclines?
Drowsiness
, Constipation
Photosensitivity
Nausea
5. Which of the following best describes the mechanism of action of ribavirin?
Inhibiting viral integration into genomic DNA
Preventing viral entry into target cells
Inhibiting viral protease activity
Interfering with the duplication of viral genetic material
Preventing uncoating of the virus
6. In a clinical scenario where a patient has a severe penicillin allergy, which
antibiotic class would be most appropriate to prescribe for a Gram-negative
bacterial infection?
Penicillins
Tetracyclines
Cephalosporins
Monobactams
7. Describe the potential adverse effects of Clindamycin and their implications
for patient care.
Clindamycin is safe and has no known adverse effects.
Clindamycin primarily affects the liver and kidneys without
gastrointestinal effects.
Clindamycin can cause diarrhea and colitis, which may lead to
serious gastrointestinal issues in patients.
, Clindamycin is only effective for skin infections and has no adverse
effects.
8. A nurse is preparing to administer medication to a patient but realizes they
are unsure about the patient's allergies. Which of the 9 rights of medication
administration is most directly impacted by this uncertainty?
Right patient
Right dose
Right medication
Right time
9. A nurse is caring for a patient prescribed a carbapenem antibiotic. What is the
primary indication for the use of carbapenems?
Prevention of parasitic infections.
Treatment of viral infections.
Targeted therapy for fungal infections.
Broad-spectrum coverage for life-threatening, resistant infections.
10. Aminoglycosides are often used in combination with other antibiotics, such
as beta-lactams or vancomycin, in the treatment of various infections
because the combined effect of the two antibiotics is greater than that of
either drug alone. The nurse is reviewing the medication orders for a patient
who will be receiving gentamicin therapy. Which other medication or
medication class, if ordered, would be a potential interaction concern?
Loop diuretics
Phenytoin
Calcium channel blockers
, Proton pump inhibitors
11. After an infusion of colistimethate (Coly-Mycin), the nurse will report to the
provider if the pt complains of which adverse effect?
Upset stomach
Insomnia
Vertigo
Dizziness
Numbness
12. If a patient is taking drug A, an enzyme inhibitor, and experiences increased
side effects from drug B, what should the nurse consider regarding the
patient's medication regimen?
Drug B should be discontinued immediately.
Drug A should be increased to counteract the effects.
No changes are necessary in the medication regimen.
The dosage of drug B may need to be adjusted.
13. Most common adverse effect associated with clindamycin
Diarrhea
Ototoxicity
Visual disturbances
QT prolongation
14. Quinolones work by...
Lysing the plasma membrane
