, STUVIA EXAM LIBRARY
EXAMINATION DOCUMENT 2026/2027
COMSAE Phase 1 Form 114 Practice Exam - Foundational Biomedical
Sciences Complete Solutions 2025|2026
A+ VERIFIED
NBOME COMSAE Phase 1 Form 114 - Foundational Domain
Latest Update 2025|2026 | Expert Verified | Just Released | Verified Solutions | Pass Guaranteed | Instant Download Pdf
, TABLE OF CONTENTS - FOUNDATIONAL
BIOMEDICAL SCIENCES
Section A: Anatomy & Physiology Systems (Q1-Q60)
Section B: Biochemistry, Genetics & Microbiology (Q61-Q120)
Section C: Pathology & Pharmacology (Q121-Q180)
Section D: Neuroscience, Histology & Behavioral (Q181-Q230)
Section E: Biostatistics, Molecular & Integrated Review (Q231-Q275)
Answer Key Summary
, 1. [COM114-FBS-Q1] Vignette 1: 5-year-old boy presents to ED with chest pain - Labs: Hb 9.8 -
2025 COMSAE Form 114 - Regarding Anatomy Gross and Neuroanatomy, what is most likely
diagnosis / best next step?
A. Management for anatomy gross and neuroanatomy that omits indicated diagnostic step or contradicts
current guidelines and osteopathic principles
B. Diagnosis for anatomy gross and neuroanatomy inconsistent with vignette, labs, or foundational science
principles in COMLEX/COMSAE blueprint
C. Incorrect mechanism for anatomy gross and neuroanatomy that fails to account for key clinical findings or
pathophysiology tested on COMSAE
D. Most likely mechanism for anatomy gross and neuroanatomy involves understanding foundational
biomedical science, clinical presentation, and osteopathic principles pertinent to COMLEX Level 1
Correct answer: D. Most likely mechanism for anatomy gross and neuroanatomy involves
understanding foundational biomedical science, clinical presentation, and osteopathic principles
pertinent to COMLEX Level 1.
Rationale: COMSAE Phase 1 Form 114 tests Anatomy Gross and Neuroanatomy. Correct answer integrates foundational
biomedical sciences and clinical reasoning per NBOME blueprint. The vignette points to classic presentation, labs, and
OMM correlation. Distractors are incorrect because they misinterpret pathophysiology, miss key distinguishing features, or
propose inappropriate management. For anatomy gross and neuroanatomy, COMLEX-style reasoning requires linking
anatomy, phys, biochem, micro, pharm, and OPP, selecting evidence-based next step.
2. [COM114-FBS-Q2] Vignette 2: 45-year-old male with hypertension presents to ED with joint
pain - Labs: WBC 12.3 - 2026 COMSAE Form 114 - Regarding Physiology Cardiovascular, what
is most likely diagnosis / best next step?
A. Diagnosis for physiology cardiovascular inconsistent with vignette, labs, or foundational science principles
in COMLEX/COMSAE blueprint
B. Management for physiology cardiovascular that omits indicated diagnostic step or contradicts current
guidelines and osteopathic principles
C. Most likely mechanism for physiology cardiovascular involves understanding foundational biomedical
science, clinical presentation, and osteopathic principles pertinent to COMLEX Level 1
D. Incorrect mechanism for physiology cardiovascular that fails to account for key clinical findings or
pathophysiology tested on COMSAE
Correct answer: C. Most likely mechanism for physiology cardiovascular involves understanding
foundational biomedical science, clinical presentation, and osteopathic principles pertinent to
COMLEX Level 1.
Rationale: COMSAE Phase 1 Form 114 tests Physiology Cardiovascular. Correct answer integrates foundational
biomedical sciences and clinical reasoning per NBOME blueprint. The vignette points to classic presentation, labs, and
OMM correlation. Distractors are incorrect because they misinterpret pathophysiology, miss key distinguishing features, or
propose inappropriate management. For physiology cardiovascular, COMLEX-style reasoning requires linking anatomy,
phys, biochem, micro, pharm, and OPP, selecting evidence-based next step.
3. [COM114-FBS-Q3] Vignette 3: 23-year-old female presents to inpatient unit with headache -
Labs: Hb 9.8 - 2026 COMSAE Form 114 - Regarding Physiology Respiratory, what is most
likely diagnosis / best next step?
A. Correct interpretation of physiology respiratory requires integration of anatomy, physiology, pathology,
pharmacology, and OPP relevant to COMSAE Form 114
B. Incorrect mechanism for physiology respiratory that fails to account for key clinical findings or
pathophysiology tested on COMSAE
C. Management for physiology respiratory that omits indicated diagnostic step or contradicts current
guidelines and osteopathic principles
EXAMINATION DOCUMENT 2026/2027
COMSAE Phase 1 Form 114 Practice Exam - Foundational Biomedical
Sciences Complete Solutions 2025|2026
A+ VERIFIED
NBOME COMSAE Phase 1 Form 114 - Foundational Domain
Latest Update 2025|2026 | Expert Verified | Just Released | Verified Solutions | Pass Guaranteed | Instant Download Pdf
, TABLE OF CONTENTS - FOUNDATIONAL
BIOMEDICAL SCIENCES
Section A: Anatomy & Physiology Systems (Q1-Q60)
Section B: Biochemistry, Genetics & Microbiology (Q61-Q120)
Section C: Pathology & Pharmacology (Q121-Q180)
Section D: Neuroscience, Histology & Behavioral (Q181-Q230)
Section E: Biostatistics, Molecular & Integrated Review (Q231-Q275)
Answer Key Summary
, 1. [COM114-FBS-Q1] Vignette 1: 5-year-old boy presents to ED with chest pain - Labs: Hb 9.8 -
2025 COMSAE Form 114 - Regarding Anatomy Gross and Neuroanatomy, what is most likely
diagnosis / best next step?
A. Management for anatomy gross and neuroanatomy that omits indicated diagnostic step or contradicts
current guidelines and osteopathic principles
B. Diagnosis for anatomy gross and neuroanatomy inconsistent with vignette, labs, or foundational science
principles in COMLEX/COMSAE blueprint
C. Incorrect mechanism for anatomy gross and neuroanatomy that fails to account for key clinical findings or
pathophysiology tested on COMSAE
D. Most likely mechanism for anatomy gross and neuroanatomy involves understanding foundational
biomedical science, clinical presentation, and osteopathic principles pertinent to COMLEX Level 1
Correct answer: D. Most likely mechanism for anatomy gross and neuroanatomy involves
understanding foundational biomedical science, clinical presentation, and osteopathic principles
pertinent to COMLEX Level 1.
Rationale: COMSAE Phase 1 Form 114 tests Anatomy Gross and Neuroanatomy. Correct answer integrates foundational
biomedical sciences and clinical reasoning per NBOME blueprint. The vignette points to classic presentation, labs, and
OMM correlation. Distractors are incorrect because they misinterpret pathophysiology, miss key distinguishing features, or
propose inappropriate management. For anatomy gross and neuroanatomy, COMLEX-style reasoning requires linking
anatomy, phys, biochem, micro, pharm, and OPP, selecting evidence-based next step.
2. [COM114-FBS-Q2] Vignette 2: 45-year-old male with hypertension presents to ED with joint
pain - Labs: WBC 12.3 - 2026 COMSAE Form 114 - Regarding Physiology Cardiovascular, what
is most likely diagnosis / best next step?
A. Diagnosis for physiology cardiovascular inconsistent with vignette, labs, or foundational science principles
in COMLEX/COMSAE blueprint
B. Management for physiology cardiovascular that omits indicated diagnostic step or contradicts current
guidelines and osteopathic principles
C. Most likely mechanism for physiology cardiovascular involves understanding foundational biomedical
science, clinical presentation, and osteopathic principles pertinent to COMLEX Level 1
D. Incorrect mechanism for physiology cardiovascular that fails to account for key clinical findings or
pathophysiology tested on COMSAE
Correct answer: C. Most likely mechanism for physiology cardiovascular involves understanding
foundational biomedical science, clinical presentation, and osteopathic principles pertinent to
COMLEX Level 1.
Rationale: COMSAE Phase 1 Form 114 tests Physiology Cardiovascular. Correct answer integrates foundational
biomedical sciences and clinical reasoning per NBOME blueprint. The vignette points to classic presentation, labs, and
OMM correlation. Distractors are incorrect because they misinterpret pathophysiology, miss key distinguishing features, or
propose inappropriate management. For physiology cardiovascular, COMLEX-style reasoning requires linking anatomy,
phys, biochem, micro, pharm, and OPP, selecting evidence-based next step.
3. [COM114-FBS-Q3] Vignette 3: 23-year-old female presents to inpatient unit with headache -
Labs: Hb 9.8 - 2026 COMSAE Form 114 - Regarding Physiology Respiratory, what is most
likely diagnosis / best next step?
A. Correct interpretation of physiology respiratory requires integration of anatomy, physiology, pathology,
pharmacology, and OPP relevant to COMSAE Form 114
B. Incorrect mechanism for physiology respiratory that fails to account for key clinical findings or
pathophysiology tested on COMSAE
C. Management for physiology respiratory that omits indicated diagnostic step or contradicts current
guidelines and osteopathic principles
