NU 578 - Controlled Substance Unit 2 Final Exam with Complete questions and correct verified answers (detailed answers) already graded A+

NU 578 - Controlled Substance Unit 2
Final Exam with Complete questions
and correct verified answers (detailed
answers) already graded A+



Tricyclic Antidepressants (TCAs) (-tryptamine) - Drug Interactions -
{✔✔RESOLUTION RESULT VERIFIED ANSWERS✔✔}-MAOIs
Sympathomimetics (epi, dopamine, etc.)
Anticholinergics
CNS depressants


Tricyclic Antidepressants (TCAs) (-tryptamine) - Contraindications/Warnings -
{✔✔RESOLUTION RESULT VERIFIED ANSWERS✔✔}-


Tricyclic Antidepressants (TCAs) (-tryptamine) - Patient Education -
{✔✔RESOLUTION RESULT VERIFIED ANSWERS✔✔}-Use 2-3 weeks before
effects are seen

,SSRI Drugs - {✔✔RESOLUTION RESULT VERIFIED ANSWERS✔✔}-Drugs:
- Fluoxetine (Prozac)
- Citalopram (Celexa),
- Escitalopram (Lexapro)
- Paroxetine (Paxil)
- Sertraline (Zoloft)
- trazodone



SSRI Action - {✔✔RESOLUTION RESULT VERIFIED ANSWERS✔✔}-Blocks
reuptake of serotonin 5-HT, which increases synaptic serotonin


Therapeutic effects are likely the result of adaptive cellular changes

SSRI Uses - {✔✔RESOLUTION RESULT VERIFIED ANSWERS✔✔}-- Depression
- Anxiety, PMDD, OCD
- MANY USES



SSRI Drug Interactions: - {✔✔RESOLUTION RESULT VERIFIED ANSWERS✔✔}-
MAOIs
TCAs
Lithium
Antiplatelet drugs



SSDI Adverse Effects - {✔✔RESOLUTION RESULT VERIFIED ANSWERS✔✔}-
Nausea, nervousness, headache, anorexia, sexual dysfunction, weight gain

,*** may increase risk of suicide = black box warnings ***



SSRI Contraindications/Warnings - {✔✔RESOLUTION RESULT VERIFIED
ANSWERS✔✔}-Serotonin syndrome




Opioids Drugs - {✔✔RESOLUTION RESULT VERIFIED ANSWERS✔✔}-Drugs:


Opioids - MOA - {✔✔RESOLUTION RESULT VERIFIED ANSWERS✔✔}-- Bind to
"opiate receptors" in the brain, which disrupts the transmission of pain signals in
the CNS.


- Mimic actions of endogenous opiates
(endorphins, enkephalins, dynorphins).


- Primarily activate mu receptors, but also activate Kappa



Opioids - Effect - {✔✔RESOLUTION RESULT VERIFIED ANSWERS✔✔}-*
Relieve pain & induce euphoria


Also cause sedation, respiratory depression, miosis, constipation, nausea, &
suppress the cough reflex.

, Opioids - Uses - {✔✔RESOLUTION RESULT VERIFIED ANSWERS✔✔}-- Pain
relief
- Cough suppression
- Relief of dyspnea
- Preoperative sedation



Opioids - Side Effects - {✔✔RESOLUTION RESULT

VERIFIED ANSWERS✔✔}-Hypotension sedation nausea
itching miosis muscle weakness constipation
Urinary Retention
Biliary Colic
Increased ICP



Treatment of Opioid- Induced Constipation - {✔✔RESOLUTION
RESULT VERIFIED ANSWERS✔✔}methylnaltrexone (Relistor)
naloxegol (Movantik)


Blocks opioid receptors in the GI tract


* Does not cross blood-brain barrier, so does not reverse analgesia



Opioids - Drug Interactions - {✔✔RESOLUTION RESULT VERIFIED
ANSWERS✔✔}-CNS depressants!


Anticholinergics