6172 Exam (Ch 7Genetic and Genomic
Considerations) Questions and
Answers.
Drugs do not metabolize the same way in all people. for what pt would a nurse expect to assess
for an alteration in drug metabolism?
A) 35 y.o. woman w/ cervical cancer b) 41. yo man w/ kidney stones
c) 50 y.o. with cirrosis of liver. d) 62 y.o woman in acute renal failure - Answer C. the liver is the
most important site of drug metabolism. if liver in not functioning effectively, as in pts with
cirrhosis, drugs will not metabolize normal so toxice levels could develop unless dosage is
reduced. pt with cervical cancer or kidney stones would not be expected to have alter abilit to
metabolize drug so long as no liver damage existed. the pt with renal failure would have altered
excretion of the drugs through the renal system but metabolism would not be impacted.
pt presents to emergency depart w/ drug level of 50 units/mL. the half-life of this drug is 1 hour.
with this drug, concentrations above 25 u/mL. are considered toxic and nomore drug is given.
how long will it take for the blood level to reach the non-toxic range?
a) 30 min B) 1 hr, C) 2hr, D) 3 hrs. - Answer B) half lifeis the time required for serum
concentration of drug to decrease by 50%. after 1 hr, the serum concentration would e 25
units/mL (50/2) if the body can properly metabolize & excrete drug. after 2 hrs, serum
concentration would be 12.5 u/ml (25/2) in 30 min drug level is 37.5, while 3 hrs the drug level
6.25
pt recently moved from vermont to Southern Florida. presnets to clinic c/o dizzy spells and
weakness. while conducting the admission assessment, pt tells nurse that he have been on the
same antihypertensive drugs for 6 yrs BP stable and no AE, since his move, he has been having
problems and feels that drug is no longer effective. clinic nurse knows that on possibie reason
for the change in effectiveness of the drug could be
a) the impact of placebo after on the pt's response.
b) the accumulative effect of drug if it has been taken for many years.
c) the impact of warmer enviorment on the pt's physical status.
D) problems with pt compliance w/ drug regimen while on vacation - Answer C. antihtn drugs
work to decrease the bp, when pt goes to climate that is much warmer than usual, blood dilate
and bp falls. if pt is taking an antiHtN drug and moves to warmer climate, there is chance to
drop to low resulting in dizziness and feeling of weakness. Even mild dehydration could
exacerbate these effects. Most antiHTN are metabolized and excreted & not accumulatre in
body. Pt must be very compliant w/ drug regimen on vacation. after several yrs on antiHTN,
effects of drug are known; therefore, the placebo effect should not be an issue.
4. an important concept taught by the nurse when providing med teaching is the need to
provide a complete list of med takjen to health care provider to avoid what?
A) spending large amt of money on meds,
Considerations) Questions and
Answers.
Drugs do not metabolize the same way in all people. for what pt would a nurse expect to assess
for an alteration in drug metabolism?
A) 35 y.o. woman w/ cervical cancer b) 41. yo man w/ kidney stones
c) 50 y.o. with cirrosis of liver. d) 62 y.o woman in acute renal failure - Answer C. the liver is the
most important site of drug metabolism. if liver in not functioning effectively, as in pts with
cirrhosis, drugs will not metabolize normal so toxice levels could develop unless dosage is
reduced. pt with cervical cancer or kidney stones would not be expected to have alter abilit to
metabolize drug so long as no liver damage existed. the pt with renal failure would have altered
excretion of the drugs through the renal system but metabolism would not be impacted.
pt presents to emergency depart w/ drug level of 50 units/mL. the half-life of this drug is 1 hour.
with this drug, concentrations above 25 u/mL. are considered toxic and nomore drug is given.
how long will it take for the blood level to reach the non-toxic range?
a) 30 min B) 1 hr, C) 2hr, D) 3 hrs. - Answer B) half lifeis the time required for serum
concentration of drug to decrease by 50%. after 1 hr, the serum concentration would e 25
units/mL (50/2) if the body can properly metabolize & excrete drug. after 2 hrs, serum
concentration would be 12.5 u/ml (25/2) in 30 min drug level is 37.5, while 3 hrs the drug level
6.25
pt recently moved from vermont to Southern Florida. presnets to clinic c/o dizzy spells and
weakness. while conducting the admission assessment, pt tells nurse that he have been on the
same antihypertensive drugs for 6 yrs BP stable and no AE, since his move, he has been having
problems and feels that drug is no longer effective. clinic nurse knows that on possibie reason
for the change in effectiveness of the drug could be
a) the impact of placebo after on the pt's response.
b) the accumulative effect of drug if it has been taken for many years.
c) the impact of warmer enviorment on the pt's physical status.
D) problems with pt compliance w/ drug regimen while on vacation - Answer C. antihtn drugs
work to decrease the bp, when pt goes to climate that is much warmer than usual, blood dilate
and bp falls. if pt is taking an antiHtN drug and moves to warmer climate, there is chance to
drop to low resulting in dizziness and feeling of weakness. Even mild dehydration could
exacerbate these effects. Most antiHTN are metabolized and excreted & not accumulatre in
body. Pt must be very compliant w/ drug regimen on vacation. after several yrs on antiHTN,
effects of drug are known; therefore, the placebo effect should not be an issue.
4. an important concept taught by the nurse when providing med teaching is the need to
provide a complete list of med takjen to health care provider to avoid what?
A) spending large amt of money on meds,
