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NR 566 Week 3 Study Guide {2020} – Johns Hopkins University Nursing
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o Drugs: benazepril, captopril, enalapril, fosinopril, lisinopril, and moexipril, perindopril, quinapril, ramipril, trandolapril o Pharmacodynamics: o MOA: Slows or inhibits the angiotensin converting enzyme which then decrease how much angiotensin II (AT II) is produced thus lowering BP o Inhibit RAAS activity=decreased production of both angiotensin II and aldosterone o Act on the RAAS system: decreases peripheral vascular resistance (decreased afterload) o Indirectly reduce the secretion of aldosterone=decreased sodium and water retention, reducing extracellular fluid volume and preload o Lower vascular resistance w/o decreasing cardiac output (CO) or GFR o Do not affect CO=Do not produce reflex tachycardia
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