Nsg 2421 Final Exam 2024 | All Questions And Correct Answers | Already
Graded A+ | Verified Answers | Latest Version
What is testosterone used for? - (CORRECT ANSWER)Males = replacement therapy for hypogonadism
associated with low or no endogenous testosterone
Females = secondary treatment to slow the growth of advanced, inoperable metastatic breast cancer
Testosterone Pharmacokinetics - (CORRECT ANSWER)Natural testosterone has high first-past effect = PO
form
Highly protein bound
Testosterone Pharmacodynamics - (CORRECT ANSWER)Males = mimics endogenous testosterone
Females = causes masculinization; slows growth of advanced breast cancers which are estrogen
dependent
Testosterone Contraindications - (CORRECT ANSWER)Serious cardiac, renal, or hepatic disease
Men with carcinomas of the breast or prostate
Pregnancy Category X
Testosterone adverse effects (males) - (CORRECT ANSWER)Gynecomastia
Excessive frequency/duration of erection
Decreased ejaculatory volume
Oligospermia (low sperm count)
Testosterone drug interactions - (CORRECT ANSWER)Only associated w/synthetic forms
1
,anticoagulants + fluoxymesterone or methyltestosterone = increased anticoagulation effects (increases
INR)
Testosterone: maximizing therapeutic effects - (CORRECT ANSWER)Administer drug at regular intervals
to maintain therapeutic testosterone levels
Apply transdermal patches on clean, dry skin on the arm, back, or upper buttocks
Suspensions = agitate vial to mix drug thoroughly before drawing it into a syringe and administering it
IM
What is important to monitor in prepubescent boys taking testosterone? - (CORRECT ANSWER)x-rays
should be taken every 6 months to assess bone age
Documents bone maturation and the effect of testosterone on the epiphyseal centers
Once the growth plate is closed, pt. will not grow anymore
When is testosterone therapy considered effective? - (CORRECT ANSWER)Development of male sex
organs and characteristics occurs normally
Pts. maintain secondary male sex characteristics without adverse effects
What is sildenafil (Viagra) used for? - (CORRECT ANSWER)Standard 1st line therapy for erectile
dysfunction
Administered PO 1 hr. before sexual activity
2
, Only effective with sexual stimulation
sildenafil (Viagra) pharmacokinetics - (CORRECT ANSWER)rapidly absorbed
peak time 60 min. when taken on an empty stomach --> absorption delayed when taken w/high-fat meal
sildenafil (Viagra) pharmacodynamics - (CORRECT ANSWER)Inhibits PDE type 5, resulting in increased
smooth muscle relaxation and improved/more sustained erection
sildenafil (Viagra) contraindications - (CORRECT ANSWER)Hypersensitivity
Nitrates = can lead to hypotension due to vasodilating effects
caution = cardiac disease (pt. needs to have a stress test before beginning treatment)
What are the most common adverse effects associated with sildenafil (Viagra)? - (CORRECT
ANSWER)facial flushing
headache
nasal congestion
heartburn
What is a rare side effect associated with sildenafil (Viagra)? - (CORRECT ANSWER)non-arterteritic
ischemic optic neuropathy
Pt. has sudden loss of vision in one or both eyes that is occasionally permanent
3
Graded A+ | Verified Answers | Latest Version
What is testosterone used for? - (CORRECT ANSWER)Males = replacement therapy for hypogonadism
associated with low or no endogenous testosterone
Females = secondary treatment to slow the growth of advanced, inoperable metastatic breast cancer
Testosterone Pharmacokinetics - (CORRECT ANSWER)Natural testosterone has high first-past effect = PO
form
Highly protein bound
Testosterone Pharmacodynamics - (CORRECT ANSWER)Males = mimics endogenous testosterone
Females = causes masculinization; slows growth of advanced breast cancers which are estrogen
dependent
Testosterone Contraindications - (CORRECT ANSWER)Serious cardiac, renal, or hepatic disease
Men with carcinomas of the breast or prostate
Pregnancy Category X
Testosterone adverse effects (males) - (CORRECT ANSWER)Gynecomastia
Excessive frequency/duration of erection
Decreased ejaculatory volume
Oligospermia (low sperm count)
Testosterone drug interactions - (CORRECT ANSWER)Only associated w/synthetic forms
1
,anticoagulants + fluoxymesterone or methyltestosterone = increased anticoagulation effects (increases
INR)
Testosterone: maximizing therapeutic effects - (CORRECT ANSWER)Administer drug at regular intervals
to maintain therapeutic testosterone levels
Apply transdermal patches on clean, dry skin on the arm, back, or upper buttocks
Suspensions = agitate vial to mix drug thoroughly before drawing it into a syringe and administering it
IM
What is important to monitor in prepubescent boys taking testosterone? - (CORRECT ANSWER)x-rays
should be taken every 6 months to assess bone age
Documents bone maturation and the effect of testosterone on the epiphyseal centers
Once the growth plate is closed, pt. will not grow anymore
When is testosterone therapy considered effective? - (CORRECT ANSWER)Development of male sex
organs and characteristics occurs normally
Pts. maintain secondary male sex characteristics without adverse effects
What is sildenafil (Viagra) used for? - (CORRECT ANSWER)Standard 1st line therapy for erectile
dysfunction
Administered PO 1 hr. before sexual activity
2
, Only effective with sexual stimulation
sildenafil (Viagra) pharmacokinetics - (CORRECT ANSWER)rapidly absorbed
peak time 60 min. when taken on an empty stomach --> absorption delayed when taken w/high-fat meal
sildenafil (Viagra) pharmacodynamics - (CORRECT ANSWER)Inhibits PDE type 5, resulting in increased
smooth muscle relaxation and improved/more sustained erection
sildenafil (Viagra) contraindications - (CORRECT ANSWER)Hypersensitivity
Nitrates = can lead to hypotension due to vasodilating effects
caution = cardiac disease (pt. needs to have a stress test before beginning treatment)
What are the most common adverse effects associated with sildenafil (Viagra)? - (CORRECT
ANSWER)facial flushing
headache
nasal congestion
heartburn
What is a rare side effect associated with sildenafil (Viagra)? - (CORRECT ANSWER)non-arterteritic
ischemic optic neuropathy
Pt. has sudden loss of vision in one or both eyes that is occasionally permanent
3
