IMMUNOHEMATOLOGY QUIZ/EXAM
QUESTIONS AND ANSWERS
Which of the following immunoglobulins is most effective in activating complement? -
Correct Answers -IgM
Human blood groups were discovered around 1900 by: - Correct Answers -Karl
Landsteiner
The gene that controls the presence of soluble H, A, and B substances in secretion is: -
Correct Answers -Se
When converting from Wiener Rh terminology to Fisher-Race Rh terminology, R1
translates to: - Correct Answers -DCe
Which of the genetic Rh group system theories states that inheritance of the five Rh
genes is controlled by the three linked alleles: Dd, Ce, Ee? - Correct Answers -Fisher-
Race Theory
The presence of which antigen on the surface of RBC membrane designates a person
as Rh-positive? - Correct Answers -D antigen
According to Landsteiner's rule, if a patient has no ABO Abs after serum testing, what
ABO antigens are present on the patient's red cells? - Correct Answers -Both A and B
antigens
A blood donor has the genotype: hh,AB. What is his red blood cell phenotype? - Correct
Answers -O
The forward grouping test identifies which of the following red blood antigens? - Correct
Answers -A and B
Which one of the weak D expressions produces anti-D? - Correct Answers -partial D
In chronic granulomatous disease (CGD), granulocyte function is impaired. An
association exists between his clinical condition and a depression of which of the
following antigens? - Correct Answers -Kell
Which of the following statements is true regarding Jk3? - Correct Answers -May
produce anti-Jk3 (anti-Jka and Anti-Jkb)
Proteolytic enzyme treatment of red cells usually destroys which antigens? - Correct
Answers -Duffy, MNS
, Resistance to malaria is best associated with which of the following blood groups? -
Correct Answers -Duffy
Which of the following Kidd group phenotypes is resistant to lysis with 2M Urea? -
Correct Answers -Jk(a-b-)
The Kell (K1) antigen is: - Correct Answers -strongly immunogenic
All of the following statements are true regarding anti-Lub except: - Correct Answers -
very common
Given the following typing results, what is the donor's racial ethnicity?
Le(a-b-); Fy(a-b-); Js(a+b+) - Correct Answers -African American
Which of the following statements is TRUE with respect to high-titer low avidity
antibodies? - Correct Answers -they react with high frequency antigens
While performing an antibody screen, a test reaction is suspected to be rouleaux. A
saline replacement test is performed and the reaction remains. What is the best
interpretation? - Correct Answers -original reaction was due to true agglutination
AHG (Coombs) control cells: - Correct Answers -are coated only with IgG antibody
Three antibodies (anti-E, anti-K, and anti-Fya) are tentatively identified by antibody ID
panel What genotype cell should be selected for confirmation of the anti-E? - Correct
Answers -E+, K-, Fy(a)-
On completion of a panel, the results are that all panel cells reacted at the same
strength in the AHG phase. The autocontrol was negative and check cells confirmed the
reaction. What may be the explanation? - Correct Answers -antibody to a high
frequency antigen
If the technologist knows the phase in which the antibody screen or antibody
identification panel is positive, then the technologist can predict which of the following? -
Correct Answers -the class of antibody
The antibody identification panel is positive in only one red cell at AHG phase. The
technologist is able to identify the Ag to which the Ab is directed. What is the next step?
- Correct Answers -choose two or more cells that are antigen positive to test
An anti-k was identified in a patient's serum but the patient's phenotype is k+. What is
the next step? - Correct Answers -review the transfusion history for a recent transfusion
QUESTIONS AND ANSWERS
Which of the following immunoglobulins is most effective in activating complement? -
Correct Answers -IgM
Human blood groups were discovered around 1900 by: - Correct Answers -Karl
Landsteiner
The gene that controls the presence of soluble H, A, and B substances in secretion is: -
Correct Answers -Se
When converting from Wiener Rh terminology to Fisher-Race Rh terminology, R1
translates to: - Correct Answers -DCe
Which of the genetic Rh group system theories states that inheritance of the five Rh
genes is controlled by the three linked alleles: Dd, Ce, Ee? - Correct Answers -Fisher-
Race Theory
The presence of which antigen on the surface of RBC membrane designates a person
as Rh-positive? - Correct Answers -D antigen
According to Landsteiner's rule, if a patient has no ABO Abs after serum testing, what
ABO antigens are present on the patient's red cells? - Correct Answers -Both A and B
antigens
A blood donor has the genotype: hh,AB. What is his red blood cell phenotype? - Correct
Answers -O
The forward grouping test identifies which of the following red blood antigens? - Correct
Answers -A and B
Which one of the weak D expressions produces anti-D? - Correct Answers -partial D
In chronic granulomatous disease (CGD), granulocyte function is impaired. An
association exists between his clinical condition and a depression of which of the
following antigens? - Correct Answers -Kell
Which of the following statements is true regarding Jk3? - Correct Answers -May
produce anti-Jk3 (anti-Jka and Anti-Jkb)
Proteolytic enzyme treatment of red cells usually destroys which antigens? - Correct
Answers -Duffy, MNS
, Resistance to malaria is best associated with which of the following blood groups? -
Correct Answers -Duffy
Which of the following Kidd group phenotypes is resistant to lysis with 2M Urea? -
Correct Answers -Jk(a-b-)
The Kell (K1) antigen is: - Correct Answers -strongly immunogenic
All of the following statements are true regarding anti-Lub except: - Correct Answers -
very common
Given the following typing results, what is the donor's racial ethnicity?
Le(a-b-); Fy(a-b-); Js(a+b+) - Correct Answers -African American
Which of the following statements is TRUE with respect to high-titer low avidity
antibodies? - Correct Answers -they react with high frequency antigens
While performing an antibody screen, a test reaction is suspected to be rouleaux. A
saline replacement test is performed and the reaction remains. What is the best
interpretation? - Correct Answers -original reaction was due to true agglutination
AHG (Coombs) control cells: - Correct Answers -are coated only with IgG antibody
Three antibodies (anti-E, anti-K, and anti-Fya) are tentatively identified by antibody ID
panel What genotype cell should be selected for confirmation of the anti-E? - Correct
Answers -E+, K-, Fy(a)-
On completion of a panel, the results are that all panel cells reacted at the same
strength in the AHG phase. The autocontrol was negative and check cells confirmed the
reaction. What may be the explanation? - Correct Answers -antibody to a high
frequency antigen
If the technologist knows the phase in which the antibody screen or antibody
identification panel is positive, then the technologist can predict which of the following? -
Correct Answers -the class of antibody
The antibody identification panel is positive in only one red cell at AHG phase. The
technologist is able to identify the Ag to which the Ab is directed. What is the next step?
- Correct Answers -choose two or more cells that are antigen positive to test
An anti-k was identified in a patient's serum but the patient's phenotype is k+. What is
the next step? - Correct Answers -review the transfusion history for a recent transfusion
