NCLEX RN Safety and Infection Control
Practice Exam 2 100 Questions And
Correct Answers (Verified Answers)
Plus Rationales 2026 Q&A Instant
Download Pdf
Question 1
A nurse is caring for a client with suspected pulmonary tuberculosis. Which
action is most appropriate?
A. Place the client in a private room with positive pressure.
B. Wear a surgical mask when entering the room.
C. Place the client in an airborne infection isolation room.
D. Keep the room door open for ventilation.
Answer: Place the client in an airborne infection isolation room.
Rationale: Tuberculosis requires airborne precautions. The client should be
placed in an airborne infection isolation room, and healthcare personnel
should use a fit-tested N95 respirator or equivalent protection.
Question 2
Which intervention is most effective for preventing healthcare-associated
infections?
A. Wearing gloves for every client interaction
B. Performing hand hygiene before and after client contact
C. Administering prophylactic antibiotics
D. Wearing a surgical mask during routine care
,Answer: Performing hand hygiene before and after client contact.
Rationale: Hand hygiene is the most important measure for preventing
transmission of microorganisms in healthcare settings.
Question 3
A nurse is caring for a client with Clostridioides difficile infection. Which action
is appropriate?
A. Use alcohol-based hand sanitizer after care.
B. Place the client on contact precautions.
C. Use a negative-pressure room.
D. Wear an N95 respirator.
Answer: Place the client on contact precautions.
Rationale: C. difficile is transmitted primarily by spores through contact.
Contact precautions and soap-and-water handwashing are required because
alcohol-based products do not reliably destroy spores.
Question 4
A nurse enters the room of a client with measles. Which personal protective
equipment is required?
A. Surgical mask
B. N95 respirator
C. Sterile gloves only
D. Face shield only
Answer: N95 respirator.
Rationale: Measles is transmitted through airborne particles. An N95
respirator or equivalent respiratory protection is required.
Question 5
,A nurse is preparing to administer medication to a client. The nurse notices
that the medication label is difficult to read. What should the nurse do?
A. Administer the medication based on the medication color.
B. Ask another nurse to identify the medication.
C. Obtain a clearly labeled medication before administration.
D. Administer the medication if the client recognizes it.
Answer: Obtain a clearly labeled medication before administration.
Rationale: Medication labels must be clearly identifiable. An unclear label
creates a medication-error risk, so the medication should not be
administered.
Question 6
A client begins experiencing a seizure while ambulating in the hallway. What is
the nurse's priority action?
A. Restrain the client's arms.
B. Insert an oral airway.
C. Protect the client from injury.
D. Give the client water.
Answer: Protect the client from injury.
Rationale: During a seizure, the priority is preventing injury. The nurse should
guide the client to a safe position, protect the head, and remove nearby
hazards.
Question 7
A hospitalized client is at high risk for falls. Which intervention is most
appropriate?
A. Keep all four side rails raised.
B. Place the call light within reach.
C. Keep the bed in the highest position.
D. Encourage the client to ambulate independently.
, Answer: Place the call light within reach.
Rationale: Keeping the call light accessible allows the client to request
assistance. The bed should be kept low, and unnecessary side rails should not
be used because they may function as restraints.
Question 8
Which client should the nurse assess first?
A. A client with a temperature of 38°C (100.4°F)
B. A client requesting assistance with bathing
C. A client receiving a blood transfusion who reports chills and back pain
D. A client waiting for discharge instructions
Answer: A client receiving a blood transfusion who reports chills and back
pain.
Rationale: Chills and back pain may indicate an acute hemolytic transfusion
reaction, which can rapidly become life-threatening.
Question 9
A nurse discovers that a client received the wrong medication. What is the
nurse's priority action?
A. Complete the incident report.
B. Notify the pharmacy.
C. Assess the client.
D. Document the error in the medical record.
Answer: Assess the client.
Rationale: After a medication error, the client's condition must be assessed
immediately. Appropriate healthcare providers are then notified and required
reporting procedures are followed.
Question 10
Practice Exam 2 100 Questions And
Correct Answers (Verified Answers)
Plus Rationales 2026 Q&A Instant
Download Pdf
Question 1
A nurse is caring for a client with suspected pulmonary tuberculosis. Which
action is most appropriate?
A. Place the client in a private room with positive pressure.
B. Wear a surgical mask when entering the room.
C. Place the client in an airborne infection isolation room.
D. Keep the room door open for ventilation.
Answer: Place the client in an airborne infection isolation room.
Rationale: Tuberculosis requires airborne precautions. The client should be
placed in an airborne infection isolation room, and healthcare personnel
should use a fit-tested N95 respirator or equivalent protection.
Question 2
Which intervention is most effective for preventing healthcare-associated
infections?
A. Wearing gloves for every client interaction
B. Performing hand hygiene before and after client contact
C. Administering prophylactic antibiotics
D. Wearing a surgical mask during routine care
,Answer: Performing hand hygiene before and after client contact.
Rationale: Hand hygiene is the most important measure for preventing
transmission of microorganisms in healthcare settings.
Question 3
A nurse is caring for a client with Clostridioides difficile infection. Which action
is appropriate?
A. Use alcohol-based hand sanitizer after care.
B. Place the client on contact precautions.
C. Use a negative-pressure room.
D. Wear an N95 respirator.
Answer: Place the client on contact precautions.
Rationale: C. difficile is transmitted primarily by spores through contact.
Contact precautions and soap-and-water handwashing are required because
alcohol-based products do not reliably destroy spores.
Question 4
A nurse enters the room of a client with measles. Which personal protective
equipment is required?
A. Surgical mask
B. N95 respirator
C. Sterile gloves only
D. Face shield only
Answer: N95 respirator.
Rationale: Measles is transmitted through airborne particles. An N95
respirator or equivalent respiratory protection is required.
Question 5
,A nurse is preparing to administer medication to a client. The nurse notices
that the medication label is difficult to read. What should the nurse do?
A. Administer the medication based on the medication color.
B. Ask another nurse to identify the medication.
C. Obtain a clearly labeled medication before administration.
D. Administer the medication if the client recognizes it.
Answer: Obtain a clearly labeled medication before administration.
Rationale: Medication labels must be clearly identifiable. An unclear label
creates a medication-error risk, so the medication should not be
administered.
Question 6
A client begins experiencing a seizure while ambulating in the hallway. What is
the nurse's priority action?
A. Restrain the client's arms.
B. Insert an oral airway.
C. Protect the client from injury.
D. Give the client water.
Answer: Protect the client from injury.
Rationale: During a seizure, the priority is preventing injury. The nurse should
guide the client to a safe position, protect the head, and remove nearby
hazards.
Question 7
A hospitalized client is at high risk for falls. Which intervention is most
appropriate?
A. Keep all four side rails raised.
B. Place the call light within reach.
C. Keep the bed in the highest position.
D. Encourage the client to ambulate independently.
, Answer: Place the call light within reach.
Rationale: Keeping the call light accessible allows the client to request
assistance. The bed should be kept low, and unnecessary side rails should not
be used because they may function as restraints.
Question 8
Which client should the nurse assess first?
A. A client with a temperature of 38°C (100.4°F)
B. A client requesting assistance with bathing
C. A client receiving a blood transfusion who reports chills and back pain
D. A client waiting for discharge instructions
Answer: A client receiving a blood transfusion who reports chills and back
pain.
Rationale: Chills and back pain may indicate an acute hemolytic transfusion
reaction, which can rapidly become life-threatening.
Question 9
A nurse discovers that a client received the wrong medication. What is the
nurse's priority action?
A. Complete the incident report.
B. Notify the pharmacy.
C. Assess the client.
D. Document the error in the medical record.
Answer: Assess the client.
Rationale: After a medication error, the client's condition must be assessed
immediately. Appropriate healthcare providers are then notified and required
reporting procedures are followed.
Question 10
