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Lehne's Pharmacology Exam 1 Ch 1-6 – Questions, Answers & Rationales

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Prepare for Lehne's Pharmacology Exam 1 Chapters 1-6 with a comprehensive study resource featuring practice questions, correct answers, and detailed rationales covering foundational pharmacology, drug classifications, pharmacokinetics, pharmacodynamics, drug absorption and distribution, metabolism, excretion, receptor interactions, medication safety, and essential concepts from Chapters 1-6 to strengthen understanding and support effective exam preparation.

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Lehne's Pharmacology
Exam 1 Ch 1-6




Practice Questions &
Answers
Comprehensive Explanations
& Rationales
Key Concepts • Review
Questions • Exam Preparation

, Pharmacokinetics The process by which drugs are absorbed, distributed , metabolized, and excreted.




Absorption determines intensity & time of the effects




3 ways to cross a cell membrane - channels and pores(electrolytes/ions)
- transport systems (P-glycoprotein)
- direct penetration of the membrane(lipid soluble)




blood-brain barrier Blood vessels (capillaries) that selectively let certain substances enter the brain
tissue and keep other substances out




Routes of Drug Administration: Parenteral-(via injection)
Intravenous, intramuscular, subcutaneous (SC)
Enteral/Oral- by mouth




drug metabolization structural enzyme change




P450 system (cytochrome P450) ox enzymes: detoxify, improves solubility to be exc by kidneys (12 enzyme families)




What enzymes of Cytochrome P450 metabolize drugs? CYP 1,2,3

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