Psio 431 Immuno Uaz Updated Actual Questions And Correct Answers

PSIO 431 IMMUNO UAZ UPDATED ACTUAL
QUESTIONS AND CORRECT ANSWERS
Question:
1. A new species of rodent is found on a tiny island. Genetic analysis shows that it is fully inbred.
When its immunoglobulin genes are examined, its H chain region shows 4 V, 3 D and 5 J segments. It
has no lambda light chains, only kappa; they have 5 V, and 3 J (there are no D regions in light chains).
So, ignoring any somatic mechanisms except V(D)J recombination, the germ line alone predicts that
this animal could make how many antibodies? 40 10,000 75 900
Answer:
900

Question:
2. Why is the quantity of IgE so low in the serum? It binds immediately to Fc receptors on Mast cells
It is mostly found floating in the tissue fluids It moves into the mucus membranes It binds
immediately to Fc receptors on neutrophils
Answer:
It binds immediately to Fc receptors on Mast cells

Question:
3. Which class of antibody has a valence of 10? IgE IgM IgG IgA
Answer:
IgM

Question:
4. My preparation of IgG anti-Streptococcus, which used to agglutinate the bacteria very effectively,
has been tampered with by my evil graduate student! Now I find that what's in the tube binds
specifically to Streptococcus, but there is no agglutination! I think that what I have now is: Fc F(ab)2
Fab Aged complement
Answer:
Fab

Question:
5. Lymphocytes are made to fit an antigen Question 5 options: True False
Answer:
False

Question:
6. Scientists are developing a new herpes vaccine. They should focus on part of the virus that is a good
___________. Question 6 options: Antigen Mitogen Epitope Immunogen
Answer:
Antigen

Question:
7. Although _____is the most effective at activating complement, ___________is the most abundant
serum immunoglobulin. Question 7 options: IgG; IgM IgA; IgM IgM; IgG IgM; IgE

,Answer:
IgM; IgG

Question:
8. I isolated a single plasma cell that was secreting IgG, and sequenced a single H chain (new
technology allows this with 100% accuracy). At the position in this image shown by the arrow, on the
Fc part of the H chain, I found the amino acid serine. That was a surprise, as almost all humans have
alanine at that position. I asked an expert in my department what the amino acid in the exact same
position on the other H chain in this particular molecule would be. What was the expert response?
There's no way to know based on the information above Because of allotypic exclusion, it will be
serine Because of allotypic exclusion, it will be alanine Statistically, it's much more likely to be
alanine
Answer:
Because of allotypic exclusion, it will be serine

Question:
9. Which of the following is the most sensitive test of antibody-antigen binding? Question 9 options:
Precipitation Hapten test Lattice test Agglutination
Answer:
Agglutination

Question:
10. Dr. Jenner showed that vaccination with Cowpox protected people from Smallpox. What is that
called? Innoculation Cross-Reaction Clonal Selection Somatic Hypermutation
Answer:
Cross-Reaction

Question:
11. Got a 9/10 on these next 10 problems

Question:
12. A fetus makes both IgM and IgG antibodies Question 1 options: True False
Answer:
False

Question:
13. I have a sample of cells from the bone marrow. What would be the first "sign" that the cell I'm
looking at is going to be a B cell? Question 2 options: cytoplasmic delta chain cytoplasmic mu chain
surface IgM surface IgD
Answer:
cytoplasmic mu chain

Question:
14. At birth an infant has 200 units of IgG antibody against rubella per ML in his blood. He is not
exposed to rubella. At 9 weeks of age, what should the concentration be? Question 3 options: 25 units
50 units 0 units, as he has not been exposed to the virus 100 units
Answer:
25 units

, Question:
15. Select the immunoglobulin class to which the statement best applies: (answers can be used more
than once)
Answer:
Composed of 21 polypeptide chains IgM
The class of the antigen receptor found on the surface of mature B cells but NOT on immature B cells
IgD
The class whose Fc portion binds to mast cells IgE

Question:
16. Clonal selection occurs in B and T lymphocytes Question 5 options: True False
Answer:
True

Question:
17. A routine sample of a newborn baby's blood is sent to the lab to be tested for antibody to
cytomegalovirus, which can cause serious developmental abnormalities in an infected fetus. The ward
clerk says the report has been called in as "positive" (there are antibodies that bind cytomegalovirus).
You think: Question 7 options: If it's IgM, I'll be worried If it's IgG and IgM,I won't worry If it's IgG,
I'll suspect a lab error If it's IgG, I'll be worried
Answer:
If it's IgG and IgM,I won't worry

Question:
18. I want to create a test to tell T cells from other cells in my dish. Which of the following markers
would NOT be useful? Question 6 options: TCR CD1 CD3 sIgM
Answer:
sIgM

Question:
19. At one month of age, the IgG in an infant's blood is: Question 8 options: Almost all made by the
mother Almost all made by the infant About equally made by infant and mother
Answer:
Almost all made by the mother

Question:
20. A pregnant woman finds out that she has been exposed to measles. She is worried that her fetus
might be infected. You take a cord (fetal) blood sample and find antibodies that bind to the measles
virus!! After calling the lab for more information, you tell the woman not to worry. What did you tell
her next? Question 9 options: The antibodies to measles were IgG, so the fetus is making it's own
immune response so not to worry The antibodies to measles were IgM, so the fetus is making it's own
immune response so not to worry The antibodies to measles were IgM, so although the mother made a
response, the fetus was not infected The antibodies to measles were IgG, so although the mother made
a response, the fetus was not infected
Answer:
The antibodies to measles were IgG, so although the mother made a response, the fetus was not
infected