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Summary Edexcel A-level Biology (SNAB 9BN0) Topic 7 Notes: Run for Your Life

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32 pages of illustrated revision notes for Topic 7. What's inside: - Joints, antagonistic muscles and synovial joints - The sarcomere and sliding filament theory, with a numbered cross-bridge cycle - Aerobic respiration: glycolysis, link reaction, Krebs cycle, oxidative phosphorylation - Anaerobic respiration, lactate and oxygen debt - Core Practical 16: respirometer, results and evaluation - The heartbeat: myogenic control and the conducting pathway - ECGs: normal and abnormal traces - Cardiac output and control of heart rate; control of breathing - Core Practical 17: spirometer traces at rest and after exercise - Muscle fibre structure; fast and slow twitch fibres - Homeostasis, negative and positive feedback, thermoregulation - Too much or too little exercise - Medical technology in sport: keyhole surgery and prostheses - Performance-enhancing substances and the ethics of their use - Transcription factors and how peptide and steroid hormones switch genes on and off

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Topic 7: Run for Your Life | Pearson Edexcel Biology A (Salters-Nuffield) / 9BN0



Joints and movement
7.1 / muscles, tendons and bones work together; antagonistic pairs


Bones are moved at joints by skeletal muscles. A muscle is attached to bone by tendons. When a muscle
contracts it shortens and pulls on the bone; a muscle cannot push, so it can only be stretched back to its
original length when the opposing muscle contracts.

Antagonistic muscles at the elbow
humerus

biceps: the flexor (front of the upper arm)
triceps: the extensor
elbow: a hinge joint
(back of the upper arm)
tendon (to the radius)

radius

tendon (to the ulna)




ulna



To flex the arm, the biceps (flexor) contracts and pulls on the radius: the arm bends (flexion). The
triceps relaxes and is stretched.
To extend the arm, the triceps (extensor) contracts and pulls on the ulna: the arm straightens
(extension). The biceps relaxes and is stretched.
A flexor bends a joint; an extensor straightens it. Two muscles that pull in opposite directions at the
same joint are an antagonistic pair.
Movement Contracts (shortens) Relaxes (is stretched)
Flexion Flexor: biceps Extensor: triceps
Extension Extensor: triceps Flexor: biceps
Write "the muscle contracts and pulls on the bone", never "pushes". Name both muscles of the pair
and say which contracts and which relaxes.




Topic 7: Run for Your Life

,Topic 7: Run for Your Life | Pearson Edexcel Biology A (Salters-Nuffield) / 9BN0



Inside a synovial joint
7.1 / ligaments, cartilage and synovial fluid allow smooth movement


Joints such as the elbow, knee and hip are synovial joints: the bones move freely against each other. The
parts of the joint hold the bones in place while reducing friction between them.

A synovial joint in section


bone

joint capsule with ligaments

synovial membrane

cartilage
synovial fluid in the joint cavity



bone




Structure What it is Function
Tendon Strong, inelastic (non-elastic) cord of Joins muscle to bone; passes on the pull
collagen. of the muscle.
Ligament Strong, flexible and slightly elastic Joins bone to bone; holds the joint
band. together and controls its movement.
Cartilage Smooth tissue covering the ends of Acts as a shock absorber and stops the
the bones. bones rubbing together.
Synovial membrane Lining of the joint capsule. Secretes synovial fluid.
Synovial fluid Liquid filling the joint cavity. Lubricates the joint: reduces friction.
Tendon = muscle to bone and must not stretch, or the pull would be lost. Ligament = bone to bone and
must stretch a little to let the joint move.




Topic 7: Run for Your Life

,Topic 7: Run for Your Life | Pearson Edexcel Biology A (Salters-Nuffield) / 9BN0



Inside a muscle fibre: the sarcomere
7.2 / actin and myosin filaments give the banding pattern


A muscle fibre is packed with myofibrils. Each myofibril is a chain of repeating units called sarcomeres,
built from two protein filaments: thin actin and thick myosin. Their overlap gives the striped appearance.

One sarcomere: relaxed and contracted
Z line M line
Relaxed




actin (thin) sarcomere
myosin (thick) A band (length of myosin)

I band H zone

Contracted




sarcomere: shorter

I band: shorter A band: unchanged H zone: shorter


Region What it is When the muscle contracts
Z line End of the sarcomere; actin is attached to it. Z lines move closer together.
I band Light band: actin only. Gets shorter.
A band Dark band: the full length of the myosin. Stays the same length.
H zone Centre of the A band: myosin only. Gets shorter.


The filaments themselves do not shorten. Actin slides between the myosin, increasing the overlap, so
the sarcomere shortens.




Topic 7: Run for Your Life

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