WGU D116 Unit 2
Study online at https://quizlet.com/_apvt4u
1. A patient receives a drug that has a narrow therapeutic range. What is the
nurse administering this medication expected to do?: Monitor plasma drug levels
Narrow therapeutic range is more difficult to administer safely because the difference between MEC and toxic
concentration is small
2. A patient is receiving intravenous gentamicin. A serum drug test reveals
toxic levels. The dosing is correct, and this medication has been tolerated by
this patient in the past.
What is a probable cause of the test result?: The pt is taking another medication that binds to
serum albumin
BGentamicin binds to albumin but weakly. In presence of another drug that binds to albumin, gentamicin can rise to
toxic levels in blood stream
3. What are the components of pharmacokinetics?: Absorption, distribution, metabolism,
excretion
4. Does the volume of distribution increase or decrease as the concentration
of a drug in the blood plasma increases?: DECREASES
5. A patient reports becoming "immune" to a medication because it no longer
works to alleviate symptoms.
The provider recognizes that this decreased effectiveness is likely caused by
what?: Desensitization of receptor sites by continual exposure to the drug
Continual exposure to an agonist would cause the cell to become less responsive or desensitized
6. What occurs when a drug binds to a receptor in the body?: It increases or decreases
the activity of that receptor
7. Which pharmacodynamic principle is most correlated with drug toxicity?: -
Therapeutic index
Which is calculated by dividing the median toxic dose by the median efficacious dose
8. A patient who is taking morphine for pain asks the nurse how a pain med-
ication can also cause constipation.
What is the nurse's response?: It is selective to receptors that regulate more than one body process
1/6
, WGU D116 Unit 2
Study online at https://quizlet.com/_apvt4u
9. Which statement about food and drug interactions is true?: Some foods can inhibit
CYP isoenzymes and alter drug metabolism
Grapefruit inhibits which lowers metabolism of drugs, leading to toxic effects of drugs
10. With respect to the cytochrome P450 (CYP) system, what will result in a
higher concentration of a drug?: Inhibition of the enzyme
Decreasing enzyme activity leads to decreased metabolism of the drug, leading to toxic effects of drug
11. An advanced practice registered nurse (APRN) works in a urology clinic
under the supervision of a physician who does not restrict the types of med-
ications the APRN is allowed to prescribe. State law does not require the APRN
to practice under physician supervision.
How would the APRN's prescriptive authority be described?: Independent because the
prescriptive authority does not require the APRN work under physician supervision
12. Which drug requires registration with the Drug Enforcement Administra-
tion (DEA) to prescribe?: Chlordiazepoxide
Schedule IV substance
All scheduled substances require the prescriber to be registered with the DEA
13. True or False
Your DEA registration allows you to prescribe Schedule II and Schedule III
controlled substances for addiction.: FALSE
Special waiver is required
14. A patient with diabetes reports losing their job and an inability to purchase
the required medications.
As the FNP, which action is most appropriate?: Contact a different pharmacy-it could decrease
the cost of the medication
15. A nurse is preparing to administer a drug. After reading the medication
guide, the nurse notes that the drug has been linked to symptoms of Parkin-
son disease in some patients.
What should the nurse do?: Observe the patient closely for such symptoms and prepare to tx them if
2/6
Study online at https://quizlet.com/_apvt4u
1. A patient receives a drug that has a narrow therapeutic range. What is the
nurse administering this medication expected to do?: Monitor plasma drug levels
Narrow therapeutic range is more difficult to administer safely because the difference between MEC and toxic
concentration is small
2. A patient is receiving intravenous gentamicin. A serum drug test reveals
toxic levels. The dosing is correct, and this medication has been tolerated by
this patient in the past.
What is a probable cause of the test result?: The pt is taking another medication that binds to
serum albumin
BGentamicin binds to albumin but weakly. In presence of another drug that binds to albumin, gentamicin can rise to
toxic levels in blood stream
3. What are the components of pharmacokinetics?: Absorption, distribution, metabolism,
excretion
4. Does the volume of distribution increase or decrease as the concentration
of a drug in the blood plasma increases?: DECREASES
5. A patient reports becoming "immune" to a medication because it no longer
works to alleviate symptoms.
The provider recognizes that this decreased effectiveness is likely caused by
what?: Desensitization of receptor sites by continual exposure to the drug
Continual exposure to an agonist would cause the cell to become less responsive or desensitized
6. What occurs when a drug binds to a receptor in the body?: It increases or decreases
the activity of that receptor
7. Which pharmacodynamic principle is most correlated with drug toxicity?: -
Therapeutic index
Which is calculated by dividing the median toxic dose by the median efficacious dose
8. A patient who is taking morphine for pain asks the nurse how a pain med-
ication can also cause constipation.
What is the nurse's response?: It is selective to receptors that regulate more than one body process
1/6
, WGU D116 Unit 2
Study online at https://quizlet.com/_apvt4u
9. Which statement about food and drug interactions is true?: Some foods can inhibit
CYP isoenzymes and alter drug metabolism
Grapefruit inhibits which lowers metabolism of drugs, leading to toxic effects of drugs
10. With respect to the cytochrome P450 (CYP) system, what will result in a
higher concentration of a drug?: Inhibition of the enzyme
Decreasing enzyme activity leads to decreased metabolism of the drug, leading to toxic effects of drug
11. An advanced practice registered nurse (APRN) works in a urology clinic
under the supervision of a physician who does not restrict the types of med-
ications the APRN is allowed to prescribe. State law does not require the APRN
to practice under physician supervision.
How would the APRN's prescriptive authority be described?: Independent because the
prescriptive authority does not require the APRN work under physician supervision
12. Which drug requires registration with the Drug Enforcement Administra-
tion (DEA) to prescribe?: Chlordiazepoxide
Schedule IV substance
All scheduled substances require the prescriber to be registered with the DEA
13. True or False
Your DEA registration allows you to prescribe Schedule II and Schedule III
controlled substances for addiction.: FALSE
Special waiver is required
14. A patient with diabetes reports losing their job and an inability to purchase
the required medications.
As the FNP, which action is most appropriate?: Contact a different pharmacy-it could decrease
the cost of the medication
15. A nurse is preparing to administer a drug. After reading the medication
guide, the nurse notes that the drug has been linked to symptoms of Parkin-
son disease in some patients.
What should the nurse do?: Observe the patient closely for such symptoms and prepare to tx them if
2/6
