RN ATI Pharmacology 2026 Retake Proctored Exam | All NGN
Level 3 Study Guide 3 Versions
This professional nursing resource is a premier test bank designed for students
preparing for the RN ATI Pharmacology Content Mastery Series (CMS) Retake
Proctored Examination. It features high-yield practice questions, 100% verified
answers, and comprehensive clinical rationales meticulously aligned with the Next
Generation NCLEX (NGN) framework. Reviewing these materials will optimize your
clinical judgment regarding medication administration safety, critical drug interactions,
lab monitoring protocols, and specific antidotes to ensure a Level 3 proficiency score
on your retake assessment
QUESTION 1
A nurse is caring for a client who is receiving alteplase for acute ischemic stroke. Which
of the following findings is the priority to report?
A. Blood pressure 150/90 mm Hg
B. Sudden onset of severe headache
C. Heart rate 88 bpm
D. Respiratory rate 18/min
Correct Answer: B
Rationale: Alteplase is a thrombolytic that can cause intracranial hemorrhage. A sudden
severe headache may indicate cerebral bleeding and requires immediate intervention.
Blood pressure (A) should be monitored but a sudden headache is more concerning. Heart
rate (C) and respiratory rate (D) are within normal limits.
QUESTION 2
A nurse is teaching a client about apixaban. Which of the following instructions should
the nurse include?
A. "You will need routine INR monitoring."
B. "Take this medication twice daily."
, C. "Avoid all NSAIDs while taking this medication."
D. "Take this medication on an empty stomach."
Correct Answer: B
Rationale: Apixaban is a direct oral anticoagulant (DOAC) typically taken twice daily.
Routine INR monitoring (A) is not required. NSAIDs (C) should be used with caution but
are not absolutely contraindicated. It can be taken with or without food (D).
QUESTION 3
A nurse is reviewing the medication list of a client taking dabigatran. Which of the
following is the reversal agent?
A. Protamine sulfate
B. Vitamin K
C. Idarucizumab
D. Andexanet alfa
Correct Answer: C
Rationale: Idarucizumab (Praxbind) is the specific reversal agent for dabigatran. Protamine
sulfate (A) is for heparin. Vitamin K (B) is for warfarin. Andexanet alfa (D) is for factor Xa
inhibitors.
QUESTION 4
A nurse is teaching a client about ticagrelor. Which of the following statements indicates
understanding?
A. "I will take this medication once daily."
B. "I will report any unusual bruising or bleeding."
, C. "I can stop taking this if I feel better."
D. "I will take this with grapefruit juice."
Correct Answer: B
Rationale: Ticagrelor is an antiplatelet agent that increases bleeding risk. Clients should
report unusual bruising or bleeding. It is taken twice daily (A). Stopping (C) without
provider guidance is unsafe. Grapefruit juice (D) can increase drug levels.
QUESTION 5
A nurse is administering filgrastim to a client receiving chemotherapy. Which of the
following findings indicates a therapeutic response?
A. Increased neutrophil count
B. Decreased neutrophil count
C. Increased platelet count
D. Decreased platelet count
Correct Answer: A
Rationale: Filgrastim stimulates neutrophil production. A therapeutic response is an
increased neutrophil count.
QUESTION 6
A nurse is reviewing the medication list of a client taking darbepoetin alfa. Which of the
following findings indicates a therapeutic response?
A. Increased hemoglobin
B. Decreased hemoglobin
C. Increased platelet count
, D. Decreased platelet count
Correct Answer: A
Rationale: Darbepoetin alfa stimulates red blood cell production. A therapeutic response is
increased hemoglobin.
QUESTION 7
A nurse is teaching a client about deferoxamine. Which of the following instructions
should the nurse include?
A. "Administer this medication subcutaneously."
B. "Take this medication orally."
C. "Take this medication with grapefruit juice."
D. "Double the dose if you miss one."
Correct Answer: A
Rationale: Deferoxamine is a chelating agent administered subcutaneously or
intravenously for iron overload.
QUESTION 8
A nurse is reviewing the medication list of a client taking romosozumab. Which of the
following findings indicates an adverse effect?
A. Cardiovascular events
B. Hypertension
C. Bradycardia
D. Hyperglycemia
Level 3 Study Guide 3 Versions
This professional nursing resource is a premier test bank designed for students
preparing for the RN ATI Pharmacology Content Mastery Series (CMS) Retake
Proctored Examination. It features high-yield practice questions, 100% verified
answers, and comprehensive clinical rationales meticulously aligned with the Next
Generation NCLEX (NGN) framework. Reviewing these materials will optimize your
clinical judgment regarding medication administration safety, critical drug interactions,
lab monitoring protocols, and specific antidotes to ensure a Level 3 proficiency score
on your retake assessment
QUESTION 1
A nurse is caring for a client who is receiving alteplase for acute ischemic stroke. Which
of the following findings is the priority to report?
A. Blood pressure 150/90 mm Hg
B. Sudden onset of severe headache
C. Heart rate 88 bpm
D. Respiratory rate 18/min
Correct Answer: B
Rationale: Alteplase is a thrombolytic that can cause intracranial hemorrhage. A sudden
severe headache may indicate cerebral bleeding and requires immediate intervention.
Blood pressure (A) should be monitored but a sudden headache is more concerning. Heart
rate (C) and respiratory rate (D) are within normal limits.
QUESTION 2
A nurse is teaching a client about apixaban. Which of the following instructions should
the nurse include?
A. "You will need routine INR monitoring."
B. "Take this medication twice daily."
, C. "Avoid all NSAIDs while taking this medication."
D. "Take this medication on an empty stomach."
Correct Answer: B
Rationale: Apixaban is a direct oral anticoagulant (DOAC) typically taken twice daily.
Routine INR monitoring (A) is not required. NSAIDs (C) should be used with caution but
are not absolutely contraindicated. It can be taken with or without food (D).
QUESTION 3
A nurse is reviewing the medication list of a client taking dabigatran. Which of the
following is the reversal agent?
A. Protamine sulfate
B. Vitamin K
C. Idarucizumab
D. Andexanet alfa
Correct Answer: C
Rationale: Idarucizumab (Praxbind) is the specific reversal agent for dabigatran. Protamine
sulfate (A) is for heparin. Vitamin K (B) is for warfarin. Andexanet alfa (D) is for factor Xa
inhibitors.
QUESTION 4
A nurse is teaching a client about ticagrelor. Which of the following statements indicates
understanding?
A. "I will take this medication once daily."
B. "I will report any unusual bruising or bleeding."
, C. "I can stop taking this if I feel better."
D. "I will take this with grapefruit juice."
Correct Answer: B
Rationale: Ticagrelor is an antiplatelet agent that increases bleeding risk. Clients should
report unusual bruising or bleeding. It is taken twice daily (A). Stopping (C) without
provider guidance is unsafe. Grapefruit juice (D) can increase drug levels.
QUESTION 5
A nurse is administering filgrastim to a client receiving chemotherapy. Which of the
following findings indicates a therapeutic response?
A. Increased neutrophil count
B. Decreased neutrophil count
C. Increased platelet count
D. Decreased platelet count
Correct Answer: A
Rationale: Filgrastim stimulates neutrophil production. A therapeutic response is an
increased neutrophil count.
QUESTION 6
A nurse is reviewing the medication list of a client taking darbepoetin alfa. Which of the
following findings indicates a therapeutic response?
A. Increased hemoglobin
B. Decreased hemoglobin
C. Increased platelet count
, D. Decreased platelet count
Correct Answer: A
Rationale: Darbepoetin alfa stimulates red blood cell production. A therapeutic response is
increased hemoglobin.
QUESTION 7
A nurse is teaching a client about deferoxamine. Which of the following instructions
should the nurse include?
A. "Administer this medication subcutaneously."
B. "Take this medication orally."
C. "Take this medication with grapefruit juice."
D. "Double the dose if you miss one."
Correct Answer: A
Rationale: Deferoxamine is a chelating agent administered subcutaneously or
intravenously for iron overload.
QUESTION 8
A nurse is reviewing the medication list of a client taking romosozumab. Which of the
following findings indicates an adverse effect?
A. Cardiovascular events
B. Hypertension
C. Bradycardia
D. Hyperglycemia
