ASCP CG CERTIFICATION EXAMINATION
TEST QUESTIONS WITH SOLUTIONS
A+
◉ nuclear shrinkage and increased basophilia = Answe: pyknosis
◉ fragmented, pyknotic nucleus = Answe: karyorrhexis
◉ architecture is preserved in what necrosis? Answe: coagulative
◉ bacteria/fungus/inflammation/enzymes are part of what necrosis?
Answe: liquifactive
◉ WBC recruitment steps Answe: margination/rolling --> adhesion -->
transmigration --> migration
◉ WBC rolling via _____ Answe: selectins
◉ WBC adhesion via ____ Answe: integrins
,◉ Virchow's triad of thrombosis Answe: endothelial injury +
stasis/turbulent blood flow + hypercoagulability
◉ most abundant collagen Answe: type I
◉ collagen in scar tissue, tendons, ligaments Answe: type I
◉ collagen in cartilage Answe: type II
◉ reticular collagen type Answe: type III
◉ BM collagen type Answe: type IV
◉ what does vWF do? Answe: helps platelets adhere to endothelium
◉ FBN1 mutation = what disorder Answe: Marfan syndrome
◉ fibrillin mutation = what disorder Answe: Marfan syndrome
◉ mutated collagen = what disorder Answe: Ehlers-Danlos
◉ musty urine odor = what disorder Answe: PKU
,◉ mutated beta-hexosaminidase A = what disorder Answe: Tay Sachs
◉ increased gangliosides = what disorder Answe: Tay Sachs
◉ mutated sphingomyelinase/increased sphingomyelin = what disorder
Answe: Neimann Pick
◉ mutated glucocerebrosidase/increased glucocerebroside = what
disorder Answe: Gaucher
◉ trisomy 13 aka Answe: Patau
◉ Patau = Answe: trisomy 13
◉ trisomy 18 aka Answe: Edwards'
◉ Edwards' = Answe: trisomy 18
◉ 3 viable trisomies Answe: 13, 18, 21
◉ maternal imprinting Answe: silencing of maternal allele
, ◉ paternal imprinting Answe: silencing of paternal allele
◉ #1 infant tumor Answe: hemangioma
◉ #1 extracranial child tumor Answe: neuroblastoma
◉ PDK1 mutation = what disorder Answe: adult PKD
◉ polycystin-1 defect = what disorder Answe: adult PKD
◉ PKHD1 mutation = what disorder Answe: childhood PKD
◉ fibrocystin defect = what disorder Answe: childhood PKD
◉ MHS2/MLH1 mutation = what disorder Answe: HNPCC/Lynch
◉ most common newborn viral infection Answe: CMV
◉ Hyaline membrane disease Answe: defective surfactant --> solid,
airless lungs in infant
TEST QUESTIONS WITH SOLUTIONS
A+
◉ nuclear shrinkage and increased basophilia = Answe: pyknosis
◉ fragmented, pyknotic nucleus = Answe: karyorrhexis
◉ architecture is preserved in what necrosis? Answe: coagulative
◉ bacteria/fungus/inflammation/enzymes are part of what necrosis?
Answe: liquifactive
◉ WBC recruitment steps Answe: margination/rolling --> adhesion -->
transmigration --> migration
◉ WBC rolling via _____ Answe: selectins
◉ WBC adhesion via ____ Answe: integrins
,◉ Virchow's triad of thrombosis Answe: endothelial injury +
stasis/turbulent blood flow + hypercoagulability
◉ most abundant collagen Answe: type I
◉ collagen in scar tissue, tendons, ligaments Answe: type I
◉ collagen in cartilage Answe: type II
◉ reticular collagen type Answe: type III
◉ BM collagen type Answe: type IV
◉ what does vWF do? Answe: helps platelets adhere to endothelium
◉ FBN1 mutation = what disorder Answe: Marfan syndrome
◉ fibrillin mutation = what disorder Answe: Marfan syndrome
◉ mutated collagen = what disorder Answe: Ehlers-Danlos
◉ musty urine odor = what disorder Answe: PKU
,◉ mutated beta-hexosaminidase A = what disorder Answe: Tay Sachs
◉ increased gangliosides = what disorder Answe: Tay Sachs
◉ mutated sphingomyelinase/increased sphingomyelin = what disorder
Answe: Neimann Pick
◉ mutated glucocerebrosidase/increased glucocerebroside = what
disorder Answe: Gaucher
◉ trisomy 13 aka Answe: Patau
◉ Patau = Answe: trisomy 13
◉ trisomy 18 aka Answe: Edwards'
◉ Edwards' = Answe: trisomy 18
◉ 3 viable trisomies Answe: 13, 18, 21
◉ maternal imprinting Answe: silencing of maternal allele
, ◉ paternal imprinting Answe: silencing of paternal allele
◉ #1 infant tumor Answe: hemangioma
◉ #1 extracranial child tumor Answe: neuroblastoma
◉ PDK1 mutation = what disorder Answe: adult PKD
◉ polycystin-1 defect = what disorder Answe: adult PKD
◉ PKHD1 mutation = what disorder Answe: childhood PKD
◉ fibrocystin defect = what disorder Answe: childhood PKD
◉ MHS2/MLH1 mutation = what disorder Answe: HNPCC/Lynch
◉ most common newborn viral infection Answe: CMV
◉ Hyaline membrane disease Answe: defective surfactant --> solid,
airless lungs in infant
