ATI Pharmacology Study Guide-Original Practice
Question Bank & Clinical Rationales Graded A+ [4
VERSIONS]
This specialized clinical test-preparation resource provides a comprehensive practice
question bank and verified answers modeled directly after the ATI Pharmacology
Content Mastery Series for . It delivers extensive pre-licensure coverage of high-alert
drug classifications, mechanism of action profiles, intricate therapeutic drug monitoring,
and safe dosage calculations across the lifespan. Nursing students will master critical
client care prioritization methods, advanced pharmacokinetic properties, and high-yield
physiological monitoring indicators to ensure an optimal proficiency level on their
proctored assessment.
1. A nurse is preparing to administer tenecteplase to a client experiencing an acute
myocardial infarction. Which assessment finding is a contraindication to this
therapy?
A) Blood pressure 150/90 mm Hg
B) Recent ischemic stroke within 3 months
C) Heart rate 88 beats/min
D) History of hypertension
Rationale: Tenecteplase is a thrombolytic; recent ischemic stroke within 3 months is a
major contraindication due to high risk of intracranial hemorrhage.
2. A client is prescribed ticagrelor. Which instruction should the nurse include in
the teaching?
A) Take with grapefruit juice
B) Avoid taking aspirin doses greater than 100 mg daily
C) Take at bedtime
D) Stop the medication if bruising occurs
,Rationale: Ticagrelor interacts with high-dose aspirin, which can reduce its effectiveness;
low-dose aspirin (≤100 mg) is recommended.
3. A nurse is administering eplerenone. Which laboratory value should be
monitored most closely?
A) Serum sodium
B) Serum potassium
C) Serum calcium
D) Serum magnesium
Rationale: Eplerenone is a selective aldosterone blocker that can cause hyperkalemia;
monitor potassium levels closely.
4. A client is prescribed aliskiren. Which instruction should the nurse include?
A) Take with a high-fat meal
B) Avoid taking with potassium supplements
C) Take at bedtime
D) Double the dose if a dose is missed
Rationale: Aliskiren is a direct renin inhibitor that can increase potassium levels; avoid
potassium supplements to prevent hyperkalemia.
5. A nurse is teaching a client about ethacrynic acid. Which adverse effect should
the nurse include?
A) Hyperkalemia
B) Ototoxicity
C) Hypertension
D) Bradycardia
Rationale: Ethacrynic acid is a loop diuretic that can cause ototoxicity, especially with
rapid IV administration or high doses.
,6. A client is prescribed fenoldopam. Which condition is this medication used to
treat?
A) Heart failure
B) Severe hypertension
C) Diabetes
D) Asthma
Rationale: Fenoldopam is a dopamine agonist used for short-term management of severe
hypertension.
7. A nurse is administering ibutilide. Which adverse effect should the nurse
monitor for?
A) Hypertension
B) QT prolongation
C) Bradycardia
D) Hyperkalemia
Rationale: Ibutilide is an antiarrhythmic that can cause QT prolongation and torsades de
pointes; monitor ECG continuously.
8. A client is prescribed flecainide. Which condition is this medication used to
treat?
A) Hypertension
B) Ventricular dysrhythmias
C) Heart failure
D) Angina
Rationale: Flecainide is a sodium channel blocker used for ventricular dysrhythmias and
certain supraventricular dysrhythmias.
, 9. A nurse is teaching a client about sotalol. Which instruction should the nurse
include?
A) Take with grapefruit juice
B) Do not stop abruptly
C) Take only when symptomatic
D) Double the dose if a dose is missed
Rationale: Sotalol is a beta-blocker with antiarrhythmic properties; abrupt discontinuation
can cause rebound hypertension, angina, or dysrhythmias.
10. A client is prescribed nedocromil. Which condition is this medication used to
treat?
A) Hypertension
B) Asthma
C) Diabetes
D) Heart failure
Rationale: Nedocromil is a mast cell stabilizer used prophylactically to prevent asthma
attacks.
11. A nurse is administering reslizumab. Which condition is this medication used
to treat?
A) COPD
B) Severe eosinophilic asthma
C) Cystic fibrosis
D) Allergic rhinitis
Rationale: Reslizumab is an anti-IL-5 monoclonal antibody used for severe eosinophilic
asthma.
12. A client is prescribed benralizumab. Which adverse effect should the nurse
monitor for?
Question Bank & Clinical Rationales Graded A+ [4
VERSIONS]
This specialized clinical test-preparation resource provides a comprehensive practice
question bank and verified answers modeled directly after the ATI Pharmacology
Content Mastery Series for . It delivers extensive pre-licensure coverage of high-alert
drug classifications, mechanism of action profiles, intricate therapeutic drug monitoring,
and safe dosage calculations across the lifespan. Nursing students will master critical
client care prioritization methods, advanced pharmacokinetic properties, and high-yield
physiological monitoring indicators to ensure an optimal proficiency level on their
proctored assessment.
1. A nurse is preparing to administer tenecteplase to a client experiencing an acute
myocardial infarction. Which assessment finding is a contraindication to this
therapy?
A) Blood pressure 150/90 mm Hg
B) Recent ischemic stroke within 3 months
C) Heart rate 88 beats/min
D) History of hypertension
Rationale: Tenecteplase is a thrombolytic; recent ischemic stroke within 3 months is a
major contraindication due to high risk of intracranial hemorrhage.
2. A client is prescribed ticagrelor. Which instruction should the nurse include in
the teaching?
A) Take with grapefruit juice
B) Avoid taking aspirin doses greater than 100 mg daily
C) Take at bedtime
D) Stop the medication if bruising occurs
,Rationale: Ticagrelor interacts with high-dose aspirin, which can reduce its effectiveness;
low-dose aspirin (≤100 mg) is recommended.
3. A nurse is administering eplerenone. Which laboratory value should be
monitored most closely?
A) Serum sodium
B) Serum potassium
C) Serum calcium
D) Serum magnesium
Rationale: Eplerenone is a selective aldosterone blocker that can cause hyperkalemia;
monitor potassium levels closely.
4. A client is prescribed aliskiren. Which instruction should the nurse include?
A) Take with a high-fat meal
B) Avoid taking with potassium supplements
C) Take at bedtime
D) Double the dose if a dose is missed
Rationale: Aliskiren is a direct renin inhibitor that can increase potassium levels; avoid
potassium supplements to prevent hyperkalemia.
5. A nurse is teaching a client about ethacrynic acid. Which adverse effect should
the nurse include?
A) Hyperkalemia
B) Ototoxicity
C) Hypertension
D) Bradycardia
Rationale: Ethacrynic acid is a loop diuretic that can cause ototoxicity, especially with
rapid IV administration or high doses.
,6. A client is prescribed fenoldopam. Which condition is this medication used to
treat?
A) Heart failure
B) Severe hypertension
C) Diabetes
D) Asthma
Rationale: Fenoldopam is a dopamine agonist used for short-term management of severe
hypertension.
7. A nurse is administering ibutilide. Which adverse effect should the nurse
monitor for?
A) Hypertension
B) QT prolongation
C) Bradycardia
D) Hyperkalemia
Rationale: Ibutilide is an antiarrhythmic that can cause QT prolongation and torsades de
pointes; monitor ECG continuously.
8. A client is prescribed flecainide. Which condition is this medication used to
treat?
A) Hypertension
B) Ventricular dysrhythmias
C) Heart failure
D) Angina
Rationale: Flecainide is a sodium channel blocker used for ventricular dysrhythmias and
certain supraventricular dysrhythmias.
, 9. A nurse is teaching a client about sotalol. Which instruction should the nurse
include?
A) Take with grapefruit juice
B) Do not stop abruptly
C) Take only when symptomatic
D) Double the dose if a dose is missed
Rationale: Sotalol is a beta-blocker with antiarrhythmic properties; abrupt discontinuation
can cause rebound hypertension, angina, or dysrhythmias.
10. A client is prescribed nedocromil. Which condition is this medication used to
treat?
A) Hypertension
B) Asthma
C) Diabetes
D) Heart failure
Rationale: Nedocromil is a mast cell stabilizer used prophylactically to prevent asthma
attacks.
11. A nurse is administering reslizumab. Which condition is this medication used
to treat?
A) COPD
B) Severe eosinophilic asthma
C) Cystic fibrosis
D) Allergic rhinitis
Rationale: Reslizumab is an anti-IL-5 monoclonal antibody used for severe eosinophilic
asthma.
12. A client is prescribed benralizumab. Which adverse effect should the nurse
monitor for?
