Barkley Oncology Exam PRACTICE
QUESTIONS |ORIGINAL QUESTIONS &
ANSWERS |DETAILED RATIONALES
|HINTED COMPLETE EXAM PREP GRADED
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1. A 58-year-old patient presents with painless hematuria. Which
malignancy should be considered particularly important in the
differential diagnosis?
A. Prostate cancer
B. Bladder cancer
C. Pancreatic cancer
D. Thyroid cancer
Answer: B. Bladder cancer
Painless gross hematuria is a classic presenting feature of urothelial
bladder carcinoma and warrants prompt evaluation.
2. Which factor is the strongest modifiable risk factor for lung
cancer?
A. Obesity
B. Alcohol consumption
C. Cigarette smoking
D. High-fat diet
Answer: C. Cigarette smoking
Smoking is the major preventable cause of lung cancer and is
associated with both small-cell and non-small-cell lung cancers.
3. Which finding is most concerning for malignant melanoma?
A. Symmetric lesion with uniform pigmentation
B. Stable 2-mm nevus
,C. Lesion demonstrating ABCDE characteristics
D. Flesh-colored papule unchanged for years
Answer: C. Lesion demonstrating ABCDE characteristics
Asymmetry, border irregularity, color variation, diameter
enlargement, and evolution are concerning features of melanoma.
4. Which laboratory abnormality is commonly associated with
multiple myeloma?
A. Hypocalcemia
B. Hypercalcemia
C. Hypoglycemia
D. Hypernatremia
Answer: B. Hypercalcemia
Myeloma-related osteolysis can release calcium into the
bloodstream, producing hypercalcemia.
5. A patient with multiple myeloma develops anemia, renal
dysfunction, and bone pain. These findings are collectively associated
with which acronym?
A. ABCD
B. CRAB
C. FAST
D. SOAP
Answer: B. CRAB
CRAB represents hyperCalcemia, Renal impairment, Anemia, and
Bone lesions, classic manifestations of symptomatic myeloma.
6. Which cancer is most strongly associated with chronic hepatitis B
or C infection?
A. Hepatocellular carcinoma
B. Colon cancer
C. Thyroid cancer
D. Bladder cancer
,Answer: A. Hepatocellular carcinoma
Chronic viral hepatitis causes persistent hepatic inflammation and
cirrhosis, substantially increasing hepatocellular carcinoma risk.
7. Which symptom is considered an alarm feature in a patient with
dyspepsia?
A. Mild intermittent bloating
B. Early satiety with progressive weight loss
C. Occasional belching
D. Symptoms after spicy foods
Answer: B. Early satiety with progressive weight loss
Unintentional weight loss and progressive early satiety can indicate
upper gastrointestinal malignancy and warrant further evaluation.
8. Which screening test is commonly used for colorectal cancer in
average-risk adults?
A. Serum amylase
B. Fecal immunochemical testing
C. CA 19-9
D. CEA alone
Answer: B. Fecal immunochemical testing
FIT detects occult blood in stool and is an accepted colorectal cancer
screening strategy.
9. Which tumor marker is commonly associated with colorectal
cancer?
A. PSA
B. CEA
C. CA-125
D. AFP
Answer: B. CEA
Carcinoembryonic antigen can be elevated in colorectal cancer and is
primarily useful for monitoring rather than screening.
, 10. Which tumor marker is associated with prostate cancer?
A. PSA
B. CA 15-3
C. AFP
D. CA-125
Answer: A. PSA
Prostate-specific antigen is produced by prostate tissue and is used in
prostate cancer evaluation and monitoring.
11. Which tumor marker is commonly associated with epithelial
ovarian cancer?
A. CA-125
B. CEA
C. PSA
D. AFP
Answer: A. CA-125
CA-125 can be elevated in epithelial ovarian cancer, although it is not
sufficiently specific for general-population screening.
12. Which tumor marker is classically associated with hepatocellular
carcinoma?
A. AFP
B. PSA
C. CA 27-29
D. Calcitonin
Answer: A. AFP
Alpha-fetoprotein may be elevated in hepatocellular carcinoma and
can assist in evaluation and surveillance.
13. Which cancer is associated with elevated calcitonin?
A. Papillary thyroid carcinoma
B. Medullary thyroid carcinoma
QUESTIONS |ORIGINAL QUESTIONS &
ANSWERS |DETAILED RATIONALES
|HINTED COMPLETE EXAM PREP GRADED
A+*INSTANT DOWNLOAD PDF
1. A 58-year-old patient presents with painless hematuria. Which
malignancy should be considered particularly important in the
differential diagnosis?
A. Prostate cancer
B. Bladder cancer
C. Pancreatic cancer
D. Thyroid cancer
Answer: B. Bladder cancer
Painless gross hematuria is a classic presenting feature of urothelial
bladder carcinoma and warrants prompt evaluation.
2. Which factor is the strongest modifiable risk factor for lung
cancer?
A. Obesity
B. Alcohol consumption
C. Cigarette smoking
D. High-fat diet
Answer: C. Cigarette smoking
Smoking is the major preventable cause of lung cancer and is
associated with both small-cell and non-small-cell lung cancers.
3. Which finding is most concerning for malignant melanoma?
A. Symmetric lesion with uniform pigmentation
B. Stable 2-mm nevus
,C. Lesion demonstrating ABCDE characteristics
D. Flesh-colored papule unchanged for years
Answer: C. Lesion demonstrating ABCDE characteristics
Asymmetry, border irregularity, color variation, diameter
enlargement, and evolution are concerning features of melanoma.
4. Which laboratory abnormality is commonly associated with
multiple myeloma?
A. Hypocalcemia
B. Hypercalcemia
C. Hypoglycemia
D. Hypernatremia
Answer: B. Hypercalcemia
Myeloma-related osteolysis can release calcium into the
bloodstream, producing hypercalcemia.
5. A patient with multiple myeloma develops anemia, renal
dysfunction, and bone pain. These findings are collectively associated
with which acronym?
A. ABCD
B. CRAB
C. FAST
D. SOAP
Answer: B. CRAB
CRAB represents hyperCalcemia, Renal impairment, Anemia, and
Bone lesions, classic manifestations of symptomatic myeloma.
6. Which cancer is most strongly associated with chronic hepatitis B
or C infection?
A. Hepatocellular carcinoma
B. Colon cancer
C. Thyroid cancer
D. Bladder cancer
,Answer: A. Hepatocellular carcinoma
Chronic viral hepatitis causes persistent hepatic inflammation and
cirrhosis, substantially increasing hepatocellular carcinoma risk.
7. Which symptom is considered an alarm feature in a patient with
dyspepsia?
A. Mild intermittent bloating
B. Early satiety with progressive weight loss
C. Occasional belching
D. Symptoms after spicy foods
Answer: B. Early satiety with progressive weight loss
Unintentional weight loss and progressive early satiety can indicate
upper gastrointestinal malignancy and warrant further evaluation.
8. Which screening test is commonly used for colorectal cancer in
average-risk adults?
A. Serum amylase
B. Fecal immunochemical testing
C. CA 19-9
D. CEA alone
Answer: B. Fecal immunochemical testing
FIT detects occult blood in stool and is an accepted colorectal cancer
screening strategy.
9. Which tumor marker is commonly associated with colorectal
cancer?
A. PSA
B. CEA
C. CA-125
D. AFP
Answer: B. CEA
Carcinoembryonic antigen can be elevated in colorectal cancer and is
primarily useful for monitoring rather than screening.
, 10. Which tumor marker is associated with prostate cancer?
A. PSA
B. CA 15-3
C. AFP
D. CA-125
Answer: A. PSA
Prostate-specific antigen is produced by prostate tissue and is used in
prostate cancer evaluation and monitoring.
11. Which tumor marker is commonly associated with epithelial
ovarian cancer?
A. CA-125
B. CEA
C. PSA
D. AFP
Answer: A. CA-125
CA-125 can be elevated in epithelial ovarian cancer, although it is not
sufficiently specific for general-population screening.
12. Which tumor marker is classically associated with hepatocellular
carcinoma?
A. AFP
B. PSA
C. CA 27-29
D. Calcitonin
Answer: A. AFP
Alpha-fetoprotein may be elevated in hepatocellular carcinoma and
can assist in evaluation and surveillance.
13. Which cancer is associated with elevated calcitonin?
A. Papillary thyroid carcinoma
B. Medullary thyroid carcinoma
